TITLE

Influence of tumor grade on expression of CA 125 in serum and tissue in patients with serous ovarian carcinoma

AUTHOR(S)
But, Igor
PUB. DATE
April 2003
SOURCE
Wiener Klinische Wochenschrift;2003, Vol. 115 Issue 7/8, p255
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objective: The factors affecting CA 125 expression in tissue in serous carcinoma are not well known. The aim of our study was to establish how CA 125 expression in serum and tissue is affected by DNA-ploidy, proliferative activity of tumor cells, tumor grade and the stage of the disease. Study design: This retrospective study included 50 patients with ovarian carcinoma. The serum CA 125 level was determined preoperatively in all patients. Antigen expression in tissue was confirmed using CA 125-immunohistochemistry. Suspensions of nuclei were prepared from tissue sections and DNA-ploidy was determined using flow cytometry. Data were analyzed using nonparametric statistics and multivariant analysis. Results: The average level of serum CA 125 was 674.5 U/ml and was significantly higher in advanced (p = 0.00044) and dedifferentiated (p = 0.00055) tumors and in tumors with a higher S-phase fraction (SPF) (p = 0.011). The mean percent of CA 125-positive cells in tissue was 38.3. CA 125 immunostaining was not related to tumor grade or DNA-ploidy. A positive CA 125 test in both tissue and serum was confirmed in 33 cases (66%). The correlation between expression of CA 125 in tissue and serum was weak (r = 0.28) and nonsignificant (p = 0.052). Conclusions: No reliable conclusions could be drawn on the influence of the studied parameters on expression of CA 125 in tissue and serum. The effect of tumor grade seems to be the strongest influence, particularly on CA 125 expression in serum, but it is not independent.
ACCESSION #
14009252

 

Related Articles

  • Prognostic relevance of induced and spontaneous apoptosis of disseminated tumor cells in primary breast cancer patients. Krawczyk, Natalia; Hartkopf, Andreas; Banys, Malgorzata; Meier-Stiegen, Franziska; Staebler, Annette; Wallwiener, Markus; Röhm, Carmen; Hoffmann, Juergen; Hahn, Markus; Fehm, Tanja // BMC Cancer;2014, Vol. 14 Issue 1, p1201 

    Background An imbalance between cell proliferation and programmed cell death can result in tumor growth. Although most systemic cytotoxic agents induce apoptosis in tumor cells, a high apoptotic rate in primary breast cancer correlates with poor prognosis. The aim of this study was to...

  • The tumor suppressor prostate apoptosis response-4 (Par-4) is regulated by mutant IDH1 and kills glioma stem cells. Liu, Yinxing; Gilbert, Misty; Kyprianou, Natasha; Rangnekar, Vivek; Horbinski, Craig // Acta Neuropathologica;Nov2014, Vol. 128 Issue 5, p723 

    Prostate apoptosis response-4 (Par-4) is an endogenous tumor suppressor that selectively induces apoptosis in a variety of cancers. Although it has been the subject of intensive research in other cancers, less is known about its significance in gliomas, including whether it is regulated by key...

  • Microchip Spots Rare Tumor Cells in Blood. Hampton, Tracy // JAMA: Journal of the American Medical Association;2/27/2008, Vol. 299 Issue 8, p889 

    The article reports that researchers from Massachusetts General Hospital in Boston created a microchip-based device which can separate moving tumor cells from outlying blood samples. The technology has identified tumor cells in cancer patients' blood and has monitored individuals' responses to...

  • Association between histology grade, expression of HsMCM2, and cyclin A in human invasive breast carcinomas. Bukholm, I.R.K.; Bukholm, G.; Holm, R.; Nesland, J.M. // Journal of Clinical Pathology;May2003, Vol. 56 Issue 5, p368 

    Aim: Increased proliferation of tumour cells has prognostic value in human invasive breast carcinomas (IBCs), and high histology grade and cyclin A expression, which may reflect high proliferation rate, are associated with poor prognosis. Expression of HsMCM2 is related to cell proliferation....

  • malignant. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p485 

    An encyclopedia entry for the term "malignancy" is presented. It refers to a condition that tends to become progressively worse and eventually lead to death. In a cancerous tumour, the term refers to the spread of cancer cells from the original site to form secondary tumours in other parts of...

  • VRK2 identifies a subgroup of primary high-grade astrocytomas with a better prognosis. Rodríguez-Hernández, Irene; Vázquez-Cedeira, Marta; Santos-Briz, Angel; Garcí, Juan L.; Fernández, Isabel F.; Gómez-Moreta, Juan A.; Martin-Vallejo, Javier; González-Sarmiento, Rogelio; Lazo, Pedro A. // BMC Clinical Pathology;2013, Vol. 13 Issue 1, p1 

    Background: Malignant astrocytomas are the most common primary brain tumors and one of the most lethal among human cancers despite optimal treatment. Therefore, the characterization of molecular alterations underlying the aggressive behavior of these tumors and the identification of new markers...

  • Nicotine and lung cancer. Warren, Graham W.; Singh, Anurag K. // Journal of Carcinogenesis;2012 Special Issue, p1 

    Tobacco use in cancer patients is associated with increased cancer treatment failure and decreased survival. Nicotine is one of over 7,000 compounds in tobacco smoke and nicotine is the principal chemical associated with addiction. The purpose of this article is to review the tumor promoting...

  • Selective Modulation of Endoplasmic Reticulum Stress Markers in Prostate Cancer Cells by a Standardized Mangosteen Fruit Extract. Li, Gongbo; Petiwala, Sakina M.; Pierce, Dana R.; Nonn, Larisa; Johnson, Jeremy J. // PLoS ONE;Dec2013, Vol. 8 Issue 12, p1 

    The increased proliferation of cancer cells is directly dependent on the increased activity of the endoplasmic reticulum (ER) machinery which is responsible for protein folding, assembly, and transport. In fact, it is so critical that perturbations in the endoplasmic reticulum can lead to...

  • Osteopontin as a potential biomarker of proliferation and invasiveness for lung cancer. Zhao, Bai; Sun, Tiemin; Meng, Fanjuan; Qu, Aibing; Li, Chunling; Shen, Hui; Jin, Yu; Li, Wenxin // Journal of Cancer Research & Clinical Oncology;Jul2011, Vol. 137 Issue 7, p1061 

    Purpose: Lung cancer is one of the most malignant tumors and poses a significant threat to human health. Osteopontin (OPN) is a variably expressed, secreted glycophosphoprotein that mediates the growth and metastases of several carcinoma types. In this study, we aimed to understand the role of...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics