"Overexpression of Erythropoietin in Sertoli Cells Enhances Testosterone Production in Leydig Cells Through Activation of JAK2/STAT5 But Not Map Kinases."

June 2004
Fertility Weekly;6/21/2004, p12
Academic Journal
Erythropoietin has been detected in primary rat Sertoli cells, and Epo receptor has been demonstrated on rat Leydig cells. In this study, we provided evidence of intercellular interaction between Sertoli cells and Leydig cells in relation to two major signaling cascades activated by Epo, namely JAK2/STAT5 and Map kinases pathways. Research findings suggest that Epo in Sertoli cells may enhance Luteinizing hormone stimulated T production in Leydig cells through JAK2/STAT5 activation. This intercellular interaction may be an important mechanism of testicular function.


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