Angiogenic cytokines in patients with idiopathic interstitial pneumonia

Simler, N. R.; Brenchley, P. E.; Horrocks, A. W.; Greaves, S. M.; Hasleton, P. S.; Egan, J. J.
July 2004
Thorax;Jul2004, Vol. 59 Issue 7, p581
Academic Journal
Background: Angiogenesis has been implicated in the pathogenesis of idiopathic interstitial pneumonia (lIP). The aim of this study was to examine the relationship between plasma concentrations of the angiogenic cytokines interleukin 8 (IL-B), vascular endothelial growth factor (VEGF), and endothelin-1 (El- 1) and clinical parameters of disease progression over a 6 month period to identify potential aetiological mediators and prognostic markers of disease activity in patients with lip. Methods: Forty nine patients with lIP (40 men) were recruited to the study. Plasma cytokine measurements, pulmonary function tests, and high resolution computed tomography (HRCT) scans were performed on recruitment and after 6 months. Plasma cytokine measurements were also performed in 15 healthy volunteers for control purposes. Results: Patients with lIP had significantly higher median (IQR) baseline concentrations of IL-8 and Er-1 than controls (155 (77-303) pg/ml v 31 (0-100) pg/ml, p<0.001) and (1.21 (0.91-1.88) pg/ml v 0.84 (0.67-1.13) pg/ml, p<0.01), respectively. Baseline concentrations of IL-8, ET-1, and VEGF were significantly related to the baseline HRCT fibrosis score (r=0.42, p<0.005; r=0.39, p<0.01; and 0.42, p<0.005, respectively). Patients with lip who developed progressive disease had significantly higher baseline levels of IL-8 (345 (270-497) pg/ml v 121(73-266) pg/ml, p =0.001) and VEGF (1048 (666-2149) pg/ml v 658 (438-837) pg/ml, p=0.019). Over 6 months the change in VEGF was significantly related to the change in HRCT fibrosis score (r=0.565, p=0.035) and negatively related to the change in forced vital capacity (r= -0.353, p=0.035).


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