Iron, anaemia, and inflammatory bowel diseases

Gasche, C.; Lomer, M. C. E.; Cavill, I.; Weiss, G.
August 2004
Gut;Aug2004, Vol. 53 Issue 8, p1190
Academic Journal
Iron deficiency anaemia is one of the most common disorders in the world. Also, one third of inflammatory bowel disease (IBD) patients suffer from recurrent anaemia. Anaemia has significant impact on the quality of life of affected patients. Chronic fatigue, a frequent IBD symptom itself, is commonly caused by anaemia and may debilitate patients as much as abdominal pain or diarrhoea. Common therapeutic targets are the mechanisms behind anaemia of chronic disease and iron deficiency. It is our experience that virtually all patients with IBD associated anaemia can be successfully treated with a combination of iron sucrose and erythropoietin, which then may positively affect the misled immune response in IBD.


Related Articles

  • Intravenous Iron Sucrose versus Oral Iron Supplementation for the Treatment of Iron Deficiency Anemia in Patients with Inflammatory Bowel Disease–A Randomized, Controlled, Open-Label, Multicenter Study. Schröder, Oliver; Mickisch, Oliver; Seidler, Ursula; de Weerth, Andreas; Dignass, Axel U.; Herfarth, Hans; Reinshagen, Max; Schreiber, Stefan; Junge, Ulrich; Schrott, Marc; Stein, Jürgen // American Journal of Gastroenterology;Nov2005, Vol. 100 Issue 11, p2503 

    OBJECTIVES: Anemia is a frequent complication in patients with inflammatory bowel disease (IBD). The optimal route for iron supplementation to replenish iron stores has not been determined so far. We therefore evaluated the efficacy and safety of intravenous iron sucrose as compared with oral...

  • Rapid Recurrence of IBD-Associated Anemia and Iron Deficiency After Intravenous Iron Sucrose and Erythropoietin Treatment. Kulnigg, Stefanie; Teischinger, Lena; Dejaco, Clemens; Waldhör, Thomas; Gasche, Christoph // American Journal of Gastroenterology;Jun2009, Vol. 104 Issue 6, p1460 

    OBJECTIVES:Anemia is a common complication of inflammatory bowel disease (IBD) and iron deficiency (ID) is its predominant cause. Therefore, oral and intravenous iron replacements are widely used. This study was performed to evaluate the frequency and timing of anemia and ID recurrence after a...

  • inflammatory bowel disease. Peters, Michael // BMA A-Z Family Medical Encyclopedia;2004, p424 

    An encyclopedia entry for "inflammatory bowel disease" is presented. It is a collective term for chronic disorders which affect the small and/or the large intestine and cause abdominal pain, bleeding and diarrhoea. The most common types of inflammatory bowel disease are Crohn's disease and...

  • Rola diety w nieswoistych zapaleniach jelit. Neubauer, Katarzyna; Poniewierka, Elzbieta // Gastroenterologia Polska / Gastroenterology;2010, Vol. 17 Issue 1, p74 

    It is currently believed that the pathogenesis of inflammatory bowel disease (IBD) includes genetic, immunological, and environmental factors. Dietetic factors are considered to be among the environmental factors. Results of epidemiological studies suggest that the diet of western countries,...

  • The Frequency and Significance of Iron-Deficiency Anemia in Patients with Selected Concurrent Illness. Huang, Joice T.; Means Jr., Robert T. // Internet Journal of Internal Medicine;2009, Vol. 8 Issue 1, p21 

    Approximately 30% of the world's population is anemic, of which 50% is iron deficiency anemia (IDA). The extent to which IDA affects patients with concomitant illneβ has not been described.A systematic review was conducted on the prevalence of IDA and its relationship to clinical outcomes in...

  • Anemia and inflammatory bowel diseases. Gomollón, Fernando; Gisbert, Javier P.; Rodrigo, Luis // World Journal of Gastroenterology;10/7/2009, Vol. 15 Issue 37, p4659 

    Too often anemia is considered a rare or unimportant manifestation in inflammatory bowel disease (IBD). However, over the last 10 years a number of studies have been conducted and the most relevant conclusions obtained are: (1) anemia is quite common in IBD; (2) although in many cases anemia...

  • Diagnosis and Management of Anemia in IBD. Evstatiev, Rayko; Gasche, Christoph // Inflammatory Bowel Disease Monitor;2011, Vol. 11 Issue 4, p152 

    With a prevalence of >30%, anemia is the most common extraintestinal complication of IBD. It impacts upon individual wellbeing, physical and mental performance, and, when severe, leads to hospitalization. Still, doctors do not recognize it early, and thus treatment is delayed. The pathogenesis...

  • Discovery Could Improve Anemia Treatment in Patients With Chronic Illness; Research Suggests a Link Between Iron Regulation and the Immune System.  // Ascribe Newswire: Medicine;4/22/2004, p44 

    Patients with chronic inflammatory disorders, including infections, inflammatory bowel disease, arthritis and cancer, commonly become anemic. Researchers at Children's Hospital Boston (CHB), Harvard Medical School, and the European Molecular Biology Laboratory have unraveled the complicated...

  • Age-related changes in hookworm infection, anaemia and iron deficiency in an area of high Necator americanus hookworm transmission in south-eastern Brazil. Brooker, Simon; Jardim-Botelho, Anne; Quinnell, Rupert J.; Geiger, Stefan M.; Caldas, Iramaya R.; Fleming, Fiona; Hotez, Peter J.; Correa-Oliveira, Rodrigo; Rodrigues, Laura C.; Bethony, Jeffrey M. // Transactions of the Royal Society of Tropical Medicine & Hygiene;Feb2007, Vol. 101 Issue 2, p146 

    Summary: Surprisingly few detailed age-stratified data exist on the epidemiology of hookworm and iron status, especially in Latin America. We present data from a cross-sectional survey examining 1332 individuals aged 0–86 years from a community in south-east Brazil for hookworm, anaemia...


Read the Article


Sign out of this library

Other Topics