Altered visceral perceptual and neuroendocrine response in patients with irritable bowel syndrome during mental stress

Posserud, I.; Agerforz, P.; Ekman, R.; Björnsson, E. S.; Abrahamsson, H.; Simrén, M.
August 2004
Gut;Aug2004, Vol. 53 Issue 8, p1102
Academic Journal
Background and aims: Stress often worsens the symptoms of irritable bowel syndrome (IBS). We hypothesised that this might be explained by altered neuroendocrine and visceral sensory responses to stress in lBS patients. Subjects and methods: Eighteen lBS patients and 22 control subjects were assessed using rectal balloon distensions before, during, and after mental stress. Ten controls and nine patients were studied in supplementary sessions. Rectal sensitivity (thresholds and intensity-visual analogue scale (VAS)) and perceived stress and arousal (VAS) were determined. Plasma levels of corticotropin releasing factor (CRF), adrenocorticotropic hormone (ACTH), cortisol, noradrenaline, and adrenaline were analysed at baseline, immediately after stress, and after the last distension. Heart rate was recorded continuously. Results: Thresholds were increased during stress in control subjects (p<0.01) but not in lBS patients. Both groups showed lower thresholds after stress (p<0.05). Repeated distensions without stress did not affect thresholds. Both groups showed increased heart rate (p<0.001) and YAS ratings for stress and arousal (p<0.05) during stress. Patients demonstrated higher ratings for stress but lower for arousal than controls. Basal CRF levels were lower in patients (p<0.05) and increased significantly during stress in patients (p<0.01) but not in controls. Patients also responded with higher levels of ACTH during stress (p<0.05) and had higher basal levels of noradrenaline than controls (p<0.01). Controls, but not patients, showed increased levels of adrenaline and noradrenaline in response to stress (p<0.05). Conclusions: Stress induced exaggeration of the neuroendocrine response and visceral perceptual alterations during and after stress may explain some of the stress related gastrointestinal symptoms in lBS.


Related Articles

  • Irritable Bowel Syndrome. Sahley, Billie J. // MMRC Health Educator Reports;2010, p1 

    The article discusses the nature of irritable bowel syndrome (IBS) and its common symptoms. The disorder affects the entire gastrointestinal tract and produces abdominal pain, constipation or diarrhea. IBS symptoms are caused by stress and anxiety. Most individuals with IBS experience bloating,...

  • Irritable bowel syndrome.  // British Journal of Community Nursing;Nov2006, Vol. 11 Issue 11, p498 

    The article reports on the launch of a new poster in Great Britain on October 2006 that is designed to assist nurses in explaining the complex symptoms associated with irritable bowel syndrome. Copies of the poster can be requested online and is supported by The IBS Network and has been produced...

  • Mind/Gut Connection.  // Joe Weider's Muscle & Fitness;Dec2008, Vol. 69 Issue 12, p50 

    The article offers information about irritable bowel syndrome (IBS) in the U.S. IBS involves abdominal pain, flatulence, diarrhea and constipation. Survey reveals that up to 15% of the country's population suffers from this condition. It notes that it has been caused by large meals and certain...

  • Exit Strategy.  // Women's Health;Nov2008, Vol. 5 Issue 9, p26 

    The article reports that a study published in "Clinical Gastroenterology and Hepatology" has found that do-it-yourself techniques can ease symptoms of irritable bowel syndrome (IBS). The cause of IBS is unclear, but doctors note a link between symptoms and stress. "Sufferers tend to worry and...

  • Editorial: New Thoughts on the Association Between Diverticulosis and Irritable Bowel Syndrome. Spiller, Robin // American Journal of Gastroenterology;Dec2014, Vol. 109 Issue 12, p1906 

    Abstract: As our population ages it is increasingly common to encounter patients with irritable bowel syndrome (IBS)-like symptoms and diverticulosis, but the nature of the association is obscure. This Editorial discusses the paper from Japan showing an association between IBS-like symptoms and...

  • Irritable bowel syndrome? Lipman, Marvin M. // Consumer Reports on Health;Jan2003, Vol. 15 Issue 1, p11 

    Discusses key issues concerning irritable bowel syndrome (IBS) in the U.S. Diagnosis; Disorders that mimic IBS; Treatment of IBS symptoms.

  • Visceral Sensitivity and Symptoms in Patients with Constipation- or Diarrhea-predominant Irritable Bowel Syndrome (IBS): Effect of a Low-Fat Intraduodenal Infusion. Caldarella, Maria Pia; Milano, Angelo; Laterza, Francesco; Sacco, Flora; Balatsinou, Crysanthi; Lapenna, Domenico; Pierdomenico, Sante Donato; Cuccurullo, Franco; Neri, Matteo // American Journal of Gastroenterology;Feb2005, Vol. 100 Issue 2, p383 

    BACKGROUND: Visceral hypersensitivity is common in Irritable Bowel Syndrome (IBS) patients, and symptoms exacerbate postprandially. Yet the effects of nutrients on visceral sensitivity and symptoms in these patients have not been fully explored.AIMS: To evaluate the differences of visceral...

  • Irritable Bowel Syndrome: Controlling Your Symptoms.  // American Family Physician;12/15/2010, Vol. 82 Issue 12, Special section p1 

    The article provides information on irritable bowel syndrome (IBS). Also known as functional bowel syndrome or irritable colon, IBS refers to an intestinal disorder which commonly starts around age 20 and is more frequent among women. Among the symptoms of IBS include bloating and gas, mucus in...

  • HANDS-ON approach to healing.  // Good Health & Medicine;Dec2007, p14 

    The article offers information on irritable bowel syndrome (IBS). People with IBS experience abnormal patterns of colonic movement. It is a functional disorder as there is no sign of disease when the colon is examined. According to a recent study in the "Journal of Gastroenterology," osteopathy,...


Read the Article


Sign out of this library

Other Topics