T helper cell polarisation in coeliac disease: any (T-)bet?

Holtmann, M. H.; Neurath, M. F.
August 2004
Gut;Aug2004, Vol. 53 Issue 8, p1065
Academic Journal
This article focuses on a study related to T helper cell polarisation in coeliac disease. The past decade has witnessed a dramatic improvement in the pathophysiological understanding of inflammatory disorders of the intestinum due to extensive research efforts focusing on regulatory mechanisms of the immune system. Normally, ingestion of food antigens such as gliadin does not elicit an immune response. Otherwise, this would be detrimental because it would lead to a permanent state of inflammation of the bowel considering the large amount of food antigens.


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