Oesophageal cancer and gastrooesophageal reflux: what is the relationship?

Lagergren, J.
August 2004
Gut;Aug2004, Vol. 53 Issue 8, p1064
Academic Journal
The direct relation between reflux and adenocarcinoma of the oesophagus has recently been addressed in several well designed population based epidemiological studies, using different study designs. The studies are all in agreement that reflux is associated with an increased risk of oesophageal adenocarcinoma in a seemingly dose dependent manner. The specific role of Barrett's oesophagus for this association was not addressed in these studies but the presence of Barrett's oesophagus has been regarded as a potential link in the causal pathway. In summary, based on the current knowledge, there seems to be a causal link between reflux and oesophageal adenocarcinoma.


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