TITLE

Cerebral injury during paediatric heart surgery: perfusion issues

AUTHOR(S)
Scallan, Michael J.H.
PUB. DATE
July 2004
SOURCE
Perfusion;Jul2004, Vol. 19 Issue 4, p221
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Suboptimal neurodevelopmental outcome is common in children who have congenital heart disease. Its aetiology is often multifactorial. This review focuses on the role of cardiopulmonary bypass. Hypothermia is the mainstay of cerebral protection. Low flow and regional low flow are preferred to deep hypothermic circulatory arrest in many situations. Cooling and rewarming, aortopulmonary collaterals, pH, air emboli, the systemic inflammatory response, haematocrit, oxygenation, glucose and ultrafiltration can influence neurodevelopmental outcome. Although no pharmacological agents have been shown to have a beneficial effect on neurodevelopmental outcome in clinical practice in children, animal work on the use of steroids several hours before surgery is encouraging.
ACCESSION #
13951284

 

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