Tau gene and Parkinson's disease: a case-control study and meta-analysis

Healy, D. G.; Abou-Sleiman, P. M.; Lees, A. J.; Casas, J. P.; Quinn, N.; Bhatia, K.; Hingorani, A. D.; Wood, N. W.
July 2004
Journal of Neurology, Neurosurgery & Psychiatry;Jul2004, Vol. 75 Issue 7, p962
Academic Journal
journal article
Objective: To investigate whether the tau H1 haplotype is a genetic risk factor in Parkinson's disease and to report a meta-analysis on all previously published dataMethods: and results: In a sample of 580 patients with Parkinson's disease and 513 controls there was an increased risk of Parkinson's disease for both the tau H1 haplotype (pConclusions: Homozygosity for the tau H1 is associated with an increased risk of Parkinson's disease. This adds to the growing body of evidence that common genetic variation contributes to the pathogenesis of this disorder.


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