Vitamin B12 (cobalamin) deficiency in elderly patients

Andrès, Emmanuel; Loukili, Noureddine H.; Noel, Esther; Kaltenbach, Georges; Abdelgheni, Maher Ben; Perrin, Anne E.; Noblet-Dick, Marie; Maloisel, Frédéric; Schlienger, Jean-Louis; Blicklé, Jean-Frédéric
August 2004
CMAJ: Canadian Medical Association Journal;8/3/2004, Vol. 171 Issue 3, p251
Academic Journal
VITAMIN B12 OR COBALAMIN DEFICIENCY occurs frequently (> 20%) among elderly people, but it is often unrecognized because the clinical manifestations are subtle; they are also potentially serious, particularly from a neuropsychiatric and hematological perspec-tive. Causes of the deficiency include, most frequently, food-cobalamin malabsorption syndrome (> 60% of all cases), perni-cious anemia (15%--20% of all cases), insufficent dietary intake and malabsorption. Food-cobalamin malabsorption, which has only recently been identified as a significant cause of cobalamin deficiency among elderly people, is characterized by the inability to release cobalamin from food or a deficiency of intestinal cobal-amin transport proteins or both. We review the epidemiology and causes of cobalamin deficiency in elderly people, with an empha-sis on food-cobalamin malabsorption syndrome. We also review diagnostic and management strategies for cobalamin deficiency.


Related Articles

  • Pernicious Anemia and Malabsorption, with Spinal Cord Degeneration Developing During Vitamin B12 Treatment. Ellis, George J.; Bruer, Richard I.; Owen, Edward E.; Laszlo, John // Annals of Internal Medicine;Mar66, Vol. 64 Issue 3, p654 

    Provides information the complications involving the deficiency in vitamin B [sub12]. Occurrence of pernicious anemia, malabsorption and spinal cord degeneration due to vitamin B [sub12] deficiency; Discussion of the absorptive defect in small intestines; Observation on neurologic disease due...

  • Vitamin B12 deficiency in a 9-month-old boy. Quentin, Christine; Huybrechts, Sophie; Rozen, Laurence; Laet, Corinne; Demulder, Anne; Ferster, Alina // European Journal of Pediatrics;Jan2012, Vol. 171 Issue 1, p193 

    We present a 9-month-old boy with megaloblastic anaemia, neutropenia and hypogammaglobulinaemia due to vitamin B12 deficiency. The deficiency was secondary to prolonged exclusive breastfeeding with inadequate nutritional amounts of vitamin B12 from the mother. There were no clinical or...

  • MEGALOBLASTIC ANEMIA - PART I. Shah, Asha // Indian Journal of Medical Sciences;Jun2004, Vol. 58 Issue 6, p258 

    Part I. Focuses on megaloblastic anemia. Deficiency in folate or cobalamin or vitamin B12; Physiology of Vitamin B12 and folic acid; Causes of B12 and folate deficiency; B12 deficiency from strictly vegetarian diets; Impairment of absorption; Defective utilization of B12 and folate due to liver...

  • Postmenopozal Kadınların Kemik Mineral YoÄŸunluÄŸunun Vitamin B12 Düzeyleri ile Ä°liÅŸkisi. Kesiktaş, Nur; Eskiyurt, Nurten; Karan, Ayşe; Akı, Semih; İşsever, Halim // From the World of Osteoporosis / Turkiye Osteoporoz Dunyasindan;2009, Vol. 15 Issue 1, p1 

    Aim: Although vitamin B12 (vit-B12) is known to influence the hemopoeitic and nervous systems, little is known about the skeletal effects of vit-B12. Researchs that demonstrated an association between serum vitamin B-12 concentration and osteoblastic function and its' role in DNA synthesis,...

  • Vitamin B12 Deficiency. Oh, Robert C.; Brown, David L. // American Family Physician;3/1/2003, Vol. 67 Issue 5, p979 

    Provides information on Vitamin B[sub12] deficiency. Diagnosis of the deficiency; Clinical manifestations; Normal absorption of Vitamin B[sub12].

  • The management of pernicious anaemia. Knott, Laurence // GP: General Practitioner;2/23/2007, p32 

    The article offers suggestions for the treatment of Pernicious anemia. Pernicious anemia is caused by impaired absorption of vitamin B12 due to a lack of intrinsic factor. The onset of symptoms is usually gradual, with dyspnoea and lethargy. The main differential diagnoses are poor diet and...

  • B12 (cobalamin) deficiency. Forman, Paul D.; Becker, Kara // Cortlandt Forum;Aug2006, Vol. 19 Issue 8, p86 

    The article provides information about the prevalence of vitamin B12 deficiency. The disease occurs to 13-15 percent of elderly patients. Deficiency to vitamin B12 can cause megaloblastic anemia and neurologic problems. Its complications include pernicious anemia, subacute combined degeneration...

  • ESPECIALLY HEPATIC HEMODYNAMICS WITH LONG DURATION OF VITAMIN B12-DEFICIENCY ANEMIA. Zaika, S. N.; Kotelnikov, V. N. // In the World of Scientific Discoveries / V Mire Nauchnykh Otkryt;2014, Vol. 50 Issue 2, p657 

    The purpose of the study was to evaluate the particularly hepatic blood flow in patients with long duration of vitamin B12-deficiency anemia, depending on the severity of the disease and analyzing the impact that the systemic circulation were examined 76 elderly patients (mean age 64,8 ± 3,5...

  • Vitamin B12 deficiency in the aged: a population-based study. Loikas, Saila // Age & Ageing;Mar2007, Vol. 36 Issue 2, p177 

    Background: vitamin B12 deficiency is common in the aged, but it is controversial whether only some risk groups should be investigated instead of screening the entire aged population. Objectives: to describe the prevalence of vitamin B12 deficiency in the Finnish aged, and to find out if the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics