TITLE

Vitamin B12 (cobalamin) deficiency in elderly patients

AUTHOR(S)
Andrès, Emmanuel; Loukili, Noureddine H.; Noel, Esther; Kaltenbach, Georges; Abdelgheni, Maher Ben; Perrin, Anne E.; Noblet-Dick, Marie; Maloisel, Frédéric; Schlienger, Jean-Louis; Blicklé, Jean-Frédéric
PUB. DATE
August 2004
SOURCE
CMAJ: Canadian Medical Association Journal;8/3/2004, Vol. 171 Issue 3, p251
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
VITAMIN B12 OR COBALAMIN DEFICIENCY occurs frequently (> 20%) among elderly people, but it is often unrecognized because the clinical manifestations are subtle; they are also potentially serious, particularly from a neuropsychiatric and hematological perspec-tive. Causes of the deficiency include, most frequently, food-cobalamin malabsorption syndrome (> 60% of all cases), perni-cious anemia (15%--20% of all cases), insufficent dietary intake and malabsorption. Food-cobalamin malabsorption, which has only recently been identified as a significant cause of cobalamin deficiency among elderly people, is characterized by the inability to release cobalamin from food or a deficiency of intestinal cobal-amin transport proteins or both. We review the epidemiology and causes of cobalamin deficiency in elderly people, with an empha-sis on food-cobalamin malabsorption syndrome. We also review diagnostic and management strategies for cobalamin deficiency.
ACCESSION #
13925133

 

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