Homocysteine-lowering therapy did not prevent stroke recurrence

Hankey, Graeme J.
July 2004
ACP Journal Club;Jul/Aug2004, Vol. 141 Issue 1, p21
Academic Journal
The article presents the information that homocysteine lowering therapy did not prevent stroke recurrence. In patients with nondisabling cerebral infarction, a multivitamin tablet with high doses of pyridoxine, cobalamin, and folic acid did not differ from a low-dose tablet for reducing recurrent stroke. 3680 patients who were ≥ 35 years of age and had nondisabling ischemic stroke and elevated total homocysteine levels. Exclusion criteria included embolic stroke, other major neurologic illness, life expectancy < 2 years, need for dialysis, and untreated anemia or vitamin B12 deficiency.


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