Review: Tricyclic and tetracyclic antidepressants are moderately effective for reducing chronic low-back pain

Underwood, Martin
July 2004
ACP Journal Club;Jul/Aug2004, Vol. 141 Issue 1, p13
Academic Journal
Tricyclic and tetracyclic antidepressants are moderately effective for reducing chronic low-back pain. Studies with insufficient data to assess treatment response were excluded. Methodological quality was assessed using a 22-point scale based on the 19-point criteria developed by the Cochrane Collaboration Back Review Group. Tricyclic or tetracyclic antidepressants are moderately effective for reducing pain in patients with chronic low-back pain. Antidepressants that do not inhibit norepinephrine reuptake show no benefit for pain relief or functional status. Although antidepressants are helpful for several painful conditions, their effectiveness for CLBP has been unclear.


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