Review: Antibiotic prophylaxis of pancreatic necrosis in acute pancreatitis reduces mortality and sepsis

Kinney, Timothy P.; Waxman, Irving
July 2004
ACP Journal Club;Jul/Aug2004, Vol. 141 Issue 1, p11
Academic Journal
The article presents the information that antibiotic prophylaxis of pancreatic necrosis in acute pancreatitis reduces mortality and sepsis. In patients with severe acute pancreatitis who have developed pancreatic necrosis, prophylactic antibiotic therapy reduces all-cause mortality and pancreatic sepsis. Superinfection of pancreatic necrosis is the most common cause of death in patients with necrotizing pancreatitis, having a mortality of up to 40% . Infection typically sets in 2 to 3 weeks after the onset of severe pancreatitis, providing a window for giving prophylactic antibiotics to prevent this complication.


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