Ximelagatran reduced venous thromboembolism more than warfarin after total knee replacement

Prandoni, Paolo
July 2004
ACP Journal Club;Jul/Aug2004, Vol. 141 Issue 1, p8
Academic Journal
The article presents the information that ximelagatran reduced venous thromboembolism more than warfarin after total knee replacement. In patients having total knee replacement, ximelagatran, 36 mg twice-daily, was more effective than warfarin in preventing venous thromboembolism. The trial by Dr. C.W. Francis and colleagues shows the superiority of a 36-mg, twice-daily dose of ximelagatran over warfarin, both started after surgery, for prevention of VTE after total knee replacement surgery. The apparent lack of hemorrhagic potential may have been because of the unusually high rate of bleeding in patients who received placebo.


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