Valsartan plus captopril did not improve survival more than captopril alone after myocardial infarction

Demers, Catherine; McKelvie, Robert S.
July 2004
ACP Journal Club;Jul/Aug2004, Vol. 141 Issue 1, p3
Academic Journal
The article presents the information that valsartan plus captopril did not improve survival more than captopril alone after myocardial infarction. In patients with myocardial infarction complicated by left ventricular systolic dysfunction, heart failure, or both, valsartan combined with captopril increased adverse events without improving survival more than captopril alone. The VALIANT trial was a large, randomized trial comparing the effects of the ARB valsartan with the ACE inhibitor captopril, and the combination of valsartan and captopril with captopril alone in patients who had acute MI with left ventricular systolic dysfunction, signs or symptoms of HF, or both.


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