Hepatitis E, Helicobacter pylori, and gastrointestinal symptoms in workers exposed to waste water

Jeggli, S.; Steiner, D.; Joller, H.; Tschopp, A.; Steffen, R.; Hotz, P.
July 2004
Occupational & Environmental Medicine;Jul2004, Vol. 61 Issue 7, p622
Academic Journal
Background: Workers exposed to sewage may have an increased risk of infection by Helicobacter pylori and hepatitis E virus (HEV). Aims: To assess the prevalence of clinical hepatitis E (HE) and peptic ulcer disease as well as the seroprevalence of antibodies to H pylori and HEV in workers with and without sewage exposure and to look for symptoms due to exposure to endotoxin. Methods: In the first year of a prospective cohort study 349 sewage exposed workers and 429 municipal manual workers (participation: 61%) underwent a complete medical examination. Travelling to endemic areas, socioeconomic level, age, country in which childhood was spent, and number of siblings were considered as the main confounding factors. Results: Peptic ulcer disease and clinical HE did not occur more often in workers exposed to sewage. Prevalence of antibodies to HEV was 3.3% and overall prevalence of IgG antibodies to H pylori was 42% with large differences between subgroups. Logistic regression did not show an increased risk of seropositivity or antibodies to parietal cells in sewage exposed workers, but disentangling the effect of exposure from that of confounders was extremely difficult. No increase of symptoms due to exposure to endotoxin was found in sewage workers, with the exception of diarrhoea. Conclusions: No clear increased risk of infection by H pylori or by HEV in workers exposed to sewage was found in this cross-sectional study, but these results need to be confirmed by follow up.


Related Articles

  • Hepatitis E, Helicobacter pylori and peptic ulcers in workers exposed to sewage: a prospective cohort study. Tschopp, A.; Joller, H.; Jeggli, S.; Widmeier, S.; Steffen, R.; Hilfiker, S.; Hotz, P. // Occupational & Environmental Medicine;Jan2009, Vol. 66 Issue 1, p45 

    Background: Workers exposed to sewage may have an increased risk of infection by Helicobacter pylori and hepatitis E virus (HEV). Objectives: To assess the incidence of clinical hepatitis E and peptic ulcers and the seroconversion rate of antibodies to H pylori and HEV in workers with and...

  • Hepatitis E. Skidmore, Susan J. // BMJ: British Medical Journal (International Edition);2/18/95, Vol. 310 Issue 6977, p414 

    Focuses on outbreaks caused by the hepatitis E virus. Resemblance of hepatitis E infection with that of hepatitis A; Fecal-oral transmission; Association of high mortality with pregnant women; Prevalence of infection in young adults.

  • Earning CME Credit.  // Emerging Infectious Diseases;Feb2011, Vol. 17 Issue 2, p334 

    Quizzes about zoonosis in the bedroom and hepatitis E virus and neurologic disorders are presented.

  • Epidemic Investigation of the Jaundice Outbreak in Girdharnagar, Ahmedabad, Gujarat, India, 2008. Chauhan, Naresh T.; Prajapati, Prakash; Trivedi, Atul V.; Bhagyalaxmi, A. // Indian Journal of Community Medicine;Apr2010, Vol. 35 Issue 2, p294 

    Background: Since 1976, seven outbreaks of hepatitis E occurred in Ahmedabad. Clusters of jaundice cases were reported on June 19, 2008, by a civic center, Girdharnagar ward, Ahmedabad. Objectives: The objectives were as follows: (1) to identify the etiological agent, source of outbreak, and...

  • Hepatitis E in England and Wales. Lewis, Hannah C.; Boisson, Sophie; Ijaz, Samreen; Hewitt, Kirsten; Siew Lin Ngui; Boxall, Elizabeth; Chong Gee Teo; Morgan, Dilys // Emerging Infectious Diseases;Jan2008, Vol. 14 Issue 1, p165 

    In 2005, 329 cases of hepatitis E virus infection were confirmed in England and Wales; 33 were confirmed indigenous infections, and a further 67 were estimated to be indigenous infections. Hepatitis E should be considered in the investigation of patients with hepatitis even if they have no...

  • Isolation and characterization of two new hepatitis E virus genotype 1 strains from two mini-outbreaks in Lahore, Pakistan. Iqbal, Tahir; Idrees, Muhammad; Ali, Liaqat; Hussain, Abrar; Ali, Muhammad; Butt, Sadia; Yousaf, Muhammad Zubair; Sabar, Muhammad Farooq // Virology Journal;2011, Vol. 8 Issue 1, p94 

    Background: Pakistan is a highly endemic area for hepatitis E virus (HEV) infection. The aim of the current study was to isolate and characterize strains of HEV in two mini outbreaks. Results: RNA was extracted and reverse transcribed to cDNA. Nested PCR was done for the detection of HEV RNA....

  • Autochthonous Hepatitis E Virus Infection in Germany with Sequence Similarities to Other European Isolates. Preiss, J. C.; Plentz, A.; Engelmann, E.; Schneider, T.; Jilg, W.; Zeitz, M.; Duchmann, R. // Infection;Jun2006, Vol. 34 Issue 3, p173 

    Hepatitis E virus (HEV) is a common cause of acute hepatitis in endemic areas. Yet reports on autochthonous cases in other areas such as middle Europe are increasing. Here we report on a patient, who obviously acquired his HEV infection in Germany. Sequence analysis of the virus gained from his...

  • A Case of Acute Hepatitis E Complicated by Acute Pancreatitis in Eastern India. Rudrajit, P.; Shubhabrata, D.; Sourav, P.; Partha, S. C.; Jayati, M.; Bhattacharya, R. // International Medical Journal Malaysia;Dec2013, Vol. 12 Issue 2, p71 

    Viral hepatitis may be occasionally associated with acute pancreatitis. Usually the patient presents with abdominal pain in the second or third week of illness. Hepatitis A or E viruses are mostly implicated. HEV related acute pancreatitis was first reported only 12 years ago. We report a case...

  • THE INCIDENCE OF ACUTE SPORADIC HEPATITIS E IN RURAL ENGLAND. Dalton, H. R.; Fellows, H. J.; Bendall, R.; Mitchell, J.; Banks, M.; Levine, D. // Gut;Apr2004 Supplement 3, Vol. 53, pA14 

    Hepatitis E is uncommon in the developed world and largely confined to people who have travelled to endemic areas. There have been several case reports of hepatitis E in patients who have not travelled to endemic areas and some evidence to support a zoonotic source of infection in such patients....


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics