TITLE

THE CD40/CD40L COSTIMULATORYU PATHWAY IN INFLAMMATORY BOWEL DISEASE

AUTHOR(S)
Danese, S.; Sans, M.; Fiocchi, C.
PUB. DATE
July 2004
SOURCE
Gut;Jul2004, Vol. 53 Issue 7, p1035
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The complexity of inflammatory bowel disease is well recognized at both the clinical and therapeutic levels. Even more complex however appears to be the unraveling of its aetiology and pathogenesis where environmental, genetic, bacterial, and immune factors come together to generate the clinical entities researchers recognize as Crohn's disease and ulcerative colitis. Initiation and progression of an immune response depends on careful regulation of lymphocyte activation. According to the classical "two signal" model, T cells require input from two sources to become fully activated. The first signal, which gives specificity to the immune response, is provided by the interaction of major histocompatibility class 2 antigens complexed to the antigen recognized by the T cell receptor.
ACCESSION #
13870137

 

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