TITLE

Identification of a genet!c marker of Helicobacter pylon strains involved in gastric extranodal marginal zone B cell lymphoma of the MALT-type

AUTHOR(S)
Lehours, P.; Dupouy, S.; Bergey, B.; Ruskoné-foumestraux, A.; Deichier, J. C.; Rod, R.; Richy, F.; Tonkovic, J.; Zerbib, F.; Mégraud, F.; Ménard, A.
PUB. DATE
July 2004
SOURCE
Gut;Jul2004, Vol. 53 Issue 7, p931
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background and aims: Gastric extranodal marginal zone B cell lymphoma of the mucosa associated lymphoid tissue (MALT)-type (MZBL) is a rare complication of Helicobacter pylon infection. Currently, no bacterial factor has been associated with the development of this disease. Our aim was to identify genes associated with lymphoma development. Methods: We used subtractive hybridisation as a tool for comparative genomics between H pylon strains isolated from a patient with gastric MZBL and from a patient with gastritis only. Results: When gastric MZBL strains were compared with gastritis strains, two open reading frames (ORFs) were significantly associated with gastric MZBL: JHP950 (74.4% v 48.7%, respectively; p=0.023) and JHP1462 (25.6% v 2.6%, respectively; p=0.004). The prevalence of JHP950 was 48.8% (p=0.024) in duodenal ulcer strains and 39.3% (p=0.006) in gastric adenocarcinoma strains, which makes this ORF a specific marker for gasfric MZBL strains. In contrast, the prevalence of JHP1462 was 16% (p = 0.545) and 35.7% (p=0.429) in duodenal ulcer and adenocarcinoma strains, respectively. These ORFs were present in reference strain J99 but not in reference strain 26695. JHP950 is located in the plasticity zone whereas the other, JHP1462, is located outside. Both encode for H pylon putative proteins with unknown functions. Conclusion: Despite its low prevalence, the ORF JHP1462 can be considered a candidate marker for H pylon strains involved in severe gastroduodenal diseases. In contrast, the ORF JHP950 has a high prevalence, and is the first candidate marker for strains giving rise to an increased risk of gastric MZBL strains. Further confirmation in other studies is needed.
ACCESSION #
13870122

 

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