TITLE

Transgenic rescue of insulin receptor--deficient mice

AUTHOR(S)
Okamoto, Haruka; Nakae, Jun; Kitamura, Tadahiro; Park, Byung-Chul; Dragatsis, Loannis; Accili, Domenico
PUB. DATE
July 2004
SOURCE
Journal of Clinical Investigation;Jul2004, Vol. 114 Issue 2, p214
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The role of different tissues in insulin action and their contribution to the pathogenesis of diabetes remain unclear. To examine this question, we have used genetic reconstitution experiments in mice. Genetic ablation of insulin receptors causes early postnatal death from diabetic ketoacidosis. We show that combined restoration of insulin receptor function in brain, liver, and pancreatic β cells rescues insulin receptor knockout mice from neonatal death, prevents diabetes in a majority of animals, and nolnializes adipose tissue content, lifespan, and reproductive function. In contrast, mice with insulin receptor expression limited to brain or liver and pancreatic β cells are rescued from neonatal death, but develop lipoatrophic diabetes and die prematurely. These data indicate, surprisingly, that insulin receptor signaling in noncanonical insulin target tissues is sufficient to maintain fuel homeostasis and prevent diabetes.
ACCESSION #
13856649

 

Related Articles

  • Design and rationale of a large, international, prospective cohort study to evaluate the occurrence of malformations and perinatal/neonatal death using insulin detemir in pregnant women with diabetes in comparison with other long-acting insulins. Mathiesen, Elisabeth R.; Andersen, Henning; Kring, Sofia I. I.; Damm, Peter // BMC Pregnancy & Childbirth;1/18/2017, Vol. 17, p1 

    Background: There are a lack of data regarding the effect of basal insulin analogues on rates of events like congenital malformation and perinatal mortality in diabetic pregnancy.Methods: The present study is a prospective, non-interventional, multicentre cohort study...

  • DIABETIC EMERGENCIES. Watkins, Peter J. // British Medical Journal (Clinical Research Edition);7/31/1982, Vol. 285 Issue 6338, p360 

    Focuses on measures on preventing ketoacidosis. Effect of insulin deficiency on ketoacidosis; Symptoms of ketoacidosis patient; Importance of diabetic control assessment on diabetic treatment.

  • Late preterm infants: severe hyperbilirubinemia and postnatal glucose homeostasis. Adamkin, D. H. // Journal of Perinatology;May2009 Supplement, Vol. 29, pS12 

    The identification of late preterm infants as a high-risk group of infants has been an important public health breakthrough. These infants have suffered a relative ‘silent morbidity and mortality’ before the recognition that they have unique physiology and risks. These infants...

  • Does the Use of Labor-inducing Drugs Cause Adverse Perinatal Outcomes? Suzuki, Shunji; Hiraizumi, Yoshie; Satomi, Misao // Journal of Nippon Medical School;2011, Vol. 78 Issue 2, p126 

    There have been several studies of adverse perinatal outcomes associated with the indiscriminate use of labor-inducing drugs. However, the present results indicate that the appropriate use of labor-inducing drugs is not unsafe and improves neonatal outcomes in abnormal deliveries.

  • Maternal morbidity and preterm birth in 22 low-and middle-income countries: a secondary analysis of the WHO Global Survey dataset. Vogel, Joshua P.; Lee, Anne C. C.; Souza, João Paulo // BMC Pregnancy & Childbirth;2014, Vol. 14 Issue 1, p1 

    Background Preterm birth (PTB) (<37weeks) complicates approximately 15 million deliveries annually, 60% occurring in low- and middle-income countries (LMICs). Several maternal morbidities increase the risk of spontaneous (spPTB) and provider-initiated (piPTB) preterm birth, but there is little...

  • CLINICAL CAPSULES.  // RN;Mar78, Vol. 41 Issue 3, p107 

    Presents articles related to medicine. Death of newborn infants due to complications from bowel perforation after insertion with rectal thermometers; Risk of a diabetic with autonomic neuropathy for cardiac arrest surgery; Procedures developed for the diagnosis of jaundice.

  • Malignant Somatostatinoma Presenting with Diabetic Ketoacidosis and Inhibitory Syndrome: Pathophysiologic Considerations. Aikaterini Theodoraki; Bernard Khoo; Arif Hamda; Frederica Grillo; Tim Meyer; Pierre-Marc Bouloux // Endocrine Practice;Sep2010, Vol. 16 Issue 5, p835 

    Objective: To describe a patient with diabetic ketoacidosis secondary to a malignant somatostatinoma.Methods: We present the clinical, laboratory, radiologic, and pathologic findings of a patient with diabetic ketoacidosis secondary to a malignant somatostatinoma. We also review the potential...

  • CETOACIDOSE DIABÉTICA: UMA REVISÃO DE LITERATURA. JACOB, THALES ABEL; SOARES, LETICIA RAMOS; SANTOS, MARINA RAMOS; SANTOS, LORENA RAMOS; SANTOS, EDUARDO RAMOS; TORRES, GUILHERME COSTA; DA SILVA, VANESSA YURI NAKAOKA ELIAS; KASHIWABARA, TATILIANA GERALDA BACELAR // Brazilian Journal of Surgery & Clinical Research;mar-mai2014, Vol. 6 Issue 2, p50 

    Diabetic ketoacidosis is a serious and potentially fatal acute complication. In Diabetes Mellitus (DM) ype 1 diabetes, it may be the prima symptom or result of increased insulin requirements because of infection, trauma, heart attacks and surgeries. Already in DM type 2 may occur under severe...

  • Misleading algorithm for management of adult patients with diabetic ketoacidosis. Kirkman, M. Sue; Juneja, Rattan; Kirkman, M S; Juneja, R // Diabetes Care;Nov2001, Vol. 24 Issue 11, p2009 

    Presents comments on study which proposed an algorithm for management of adult patients with diabetic ketoacidosis, from the January 2001 issue of 'Diabetes Care.' Limitations of the algorithm on subcutaneous insulin; Concern over the term sliding scale.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics