Linezolid-Associated Peripheral Neuropathy

Rho, Jennifer P.; Sia, Irenge G.; Crum, Brian A.; Dekutoski, Mark B.; Trousdale, Robert T.
July 2004
Mayo Clinic Proceedings;Jul2004, Vol. 79 Issue 7, p927
Academic Journal
Linezolid is the first drug in a new class of synthetic antimicrobials, the oxazolidinones, to be approved by the Food and Drug Administration. Linezolid is active against methicillin- and vancomycin-resistant gram-positive microorganisms. We describe 2 patients who developed peripheral neuropathy after prolonged treatment with linizolid. Linezolid-associated peripheral neuropathy has not been well documented. Most reported cases of linezolid-associated peripheral neuropathy have occurred in patients who took linezolid for a period longer than the recommended 28 or fewer days. Health care providers must be alert to the potential for serious adverse effects associated with linezolid use, including peripheral neuropathy.


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