Thalidomide: Tragic Past and Promising Future
- Guidance Values for Surface Monitoring of Antineoplastic Drugs in German Pharmacies. Schierl, Rudolf; Böhlandt, Antje; Nowak, Dennis // Annals of Occupational Hygiene;Oct2009, Vol. 53 Issue 7, p703
Objectives: Antineoplastic drugs are widely used in anticancer therapy due to their cytotoxic activity but many of them are classified as carcinogenic, mutagenic, or teratogenic to humans. In order to evaluate personal exposure, surface monitoring has been successfully applied for several years....
- Suffer the Children: The Story of Thalidomide. Mintz, Morton // New Republic;4/21/79, Vol. 180 Issue 16, p30
Reviews the book "Suffer the Children: The Story of Thalidomide," by The Insight Team of The Sunday Times of London.
- Teratogenic risk and contraceptive counselling in psychiatric practice: analysis of anticonvulsant therapy. Langan, Julie; Perry, Andrea; Oto, Maria // BMC Psychiatry;2013, Vol. 13 Issue 1, p1
Background: Anticonvulsants have been used to manage psychiatric conditions for over 50 years. It is recognised that some, particularly valproate, carbamazepine and lamotrigine, are human teratogens, while others including topiramate require further investigation. We aimed to appraise the...
- Teratogen. Vohr, Hans-Werner // Encyclopedic Reference of Immunotoxicology;2005, p629
A definition for the term "teratogen" is presented. It refers to any substance or exposure that causes birth defects.
- Is the use of letrozole to induce ovulation teratogenic? Kaur Gill, Simerpal; Moretti, Myla; Koren, Gideon // Canadian Family Physician;Mar2008, Vol. 54, p353
QUESTION A patient of mine has been prescribed letrozole to induce ovulation; however, a recent release from the Food and Drug Administration contraindicates the use of letrozole in premenopausal women owing to teratogenicity. Does the use of letrozole increase the risk of a child being born...
- Developmental Defects: A Final Common Pathway of Teratogenicity? Goldman, Allen S. // Clinical Pediatrics;Nov1973, Vol. 12 Issue 11, p627
Comments on the developmental defects of fetus caused by teratogenic agents. Diseases associated with leukocytosis; Common pathway of teratogenic agents; Speculations on the neurohormonal effects of the teratogens which may alter tissue permeability; Administration of sodium bicarbonate to...
- Teratogenic. // Encyclopedic Reference of Cancer;2001, p886
An encyclopedia entry for teratogenic is presented. Teratogenic substances produce developmental malformations during gestation.
- Thalidomide: When Everything Old Is New Again. Nirenberg, Anita // Clinical Journal of Oncology Nursing;Jan/Feb2001, Vol. 5 Issue 1, p1
Thalidomide is an anti-angiogenesis agent that currently is being evaluated in the treatment of various types of cancer. The teratogenic effects of thalidomide are well-known, and patients who are prescribed this drug often are fearful of its effects. Because of the potential for teratogenicity,...
- An Ongoing Epidemic of Birth Defects. Cossio, Gladys; Bissot, Alberto; de Rivas, Mireya; Morales, Luis; Gallardo, Paul; Ellis, David; Hall, Judith // Pharmacology & Pharmacy;Jun2013, Vol. 4 Issue 3, p312
In the 1990s, misoprostol (synthetic prostaglandin E1 analogue) was found to be an effective abortive agent when taken orally and became widely used in Latin America as a means to terminate unwanted pregnancies. A variety of congenital anomalies have been observed among the children of women who...