Antioxidant vitamins (A, C and E) and malondialdehyde levels in acute exacerbation and stable periods of patients with chronic obstructive pulmonary disease

Tug, Tuncer; Karatas, Fikret; Terzi, Selim Murat
June 2004
Clinical & Investigative Medicine;Jun2004, Vol. 27 Issue 3, p123
Academic Journal
Background: People with chronic obstructive pulmonary disease (COPD) undergo oxidative damage during exacerbations that continues in stable periods, gradually contributing to pathogenesis. Since serum concentrations of antioxidant vitamins in COPD patients have been little investigated, we studied antioxidant vitamin and lipid peroxidation concentrations in patients during acute exacerbations and stable periods. Methods: We prospectively recruited 24 patients with COPD (mean age 51.8 yr, standard deviation [SD] 6.7 yr) in acute exacerbation. Serum concentrations of vitamins A, C and E and malondialdehyde (MDA) were determined before treatment and during stable periods with high-performance liquid chromatography, and in 23 healthy controls (mean age 48.0 yr; SD 5.9 yr) with established methods. Results: The mean vitamin A level in patients during acute exacerbation was 0.8 (SD 0.2) μg/mL, rising to 1.0 (SD 0.2) μg/mL during stable periods, both significantly less than that of controls (1.0 [SD 0.2] μg/mL; p < 0.01); vitamin C, 5.0 (SD 2.2) μg/mL acute and 7.5 (SD 2.7) stable, neither significantly differing from the mean level in controls (8.6 [SD 1.8] μg/mL; p > 0.05); vitamin E, 10.0 (SD 2.4) μg/mL acute and 11.1 (SD 2.6) stable, both lower than in controls (11.0 [SD 2.86] μg/mL; p < 0.01); and MDA, 2.4 (SD 0.7) nmol/mL acute and 1.2 (SD 0.4) stable, both higher than in controls (0.9 [SD 0.2] nmol/mL; p < 0.01). Conclusions: Whereas patients with COPD undergo increased oxidative stress during exacerbations and in stable periods, their serum concentrations of antioxidant vitamins A and E decrease during exacerbations. Our findings suggest that the administration of vitamins A and E may be beneficial in the prevention and treatment of the harmful effects of COPD.


Related Articles

  • Purification of Pomegranate Pericarps (Punica granatum L.) Extracts with Macroporous Resins and Evaluation of Antioxidant Activities in Vivo. Benhong Zhou; Jie Tu; Jing Zhou; Huilan Yi; Yue Wu; Gang Liu // Advanced Materials Research;2014, Vol. 998-999, p296 

    Punica granatum L. Pomegranate has been traditionally used as a folk fruits for centuries in Oriental countries. It extract and subsequent fractions were used to evaluate antioxidant and related activities of Punica granatum L. It were extracted by 70% acetone, and then purified by HPD-400...

  • Phenolic Compounds Protect Cultured Hippocampal Neurons against Ethanol-Withdrawal Induced Oxidative Stress. Prokai-Tatrai, Katalin; Prokai, Laszlo; Simpkins, James W.; Jung, Marianna E. // International Journal of Molecular Sciences;Apr2009, Vol. 10 Issue 4, p1773 

    Ethanol withdrawal is linked to elevated oxidative damage to neurons. Here we report our findings on the contribution of phenolic antioxidants (17β-estradiol, p-octylphenol and 2,6-di-tert-butyl-4-methylphenol) to counterbalance sudden ethanol withdrawal-initiated oxidative events in...

  • Antioxidant enzyme and malondialdehyde values in social phobia before and after citalopram treatment. Atmaca, Murad; Tezcan, Ertan; Kuloglu, Murat; Ustundag, Bilal; Tunckol, Hikmet // European Archives of Psychiatry & Clinical Neuroscience;2004, Vol. 254 Issue 4, p231 

    A growing body of evidence indicates that oxidative stress is involved in the etiopathogenesis of some psychiatric disorders. In our previous study, we have found that social phobia (SP) seems to be associated with elevated antioxidant enzymes and malondialdehyde (MDA) levels, a lipid...

  • Antioxidant-rich spice added to hamburger meat during cooking results in reduced meat, plasma, and urine malondialdehyde concentrations.  // American Journal of Clinical Nutrition;May2010, Vol. 91 Issue 5, p1180 

    The article presents a study that examines the effect of an antioxidant spice mixture on malondialdehyde formation while cooking hamburger meat and its effects on plasma and urinary malondialdehyde concentrations. The study included 11 heathy volunteers who consumed two kinds of burgers. It...

  • Effect of Vitamin E-stored Experimental Blood Samples on Malondialdehyde and Protein Concentrati. Ogugua Victor, N.; Emmanuel Tufon, N.; Enechi Osmond, C. // Asian Journal of Research in Chemistry;Jun2012, Vol. 5 Issue 6, p765 

    The continuous fluctuation in power supply in some developing countries has been suggested to be one of the contributing factors that affect stored experimental blood samples leading to errors in laboratory results. The study was therefore aimed at evaluating the effect of vitamin-E stored blood...

  • The effects of exogenous interleukin-4 on hypoxia-induced lung injury. Ozturk, Hayrettin; Ozturk, Hulya; Buyukbayram, Huseyin; Tuncer, Mehmet Cudi // Pediatric Surgery International;Feb2006, Vol. 22 Issue 2, p197 

    The aim of this study was to determine the effects of recombinant human interleukin-4 (rhIL-4) on hypoxia-induced lung injury in immature rats. The study was performed on 1-day-old Sprague Dawley rat pups. Group 1 (n = 7) served as nonhypoxic controls. Group 2 (untreated, n = 7) rats were...

  • Lung Function in Relation to Intake of Carotenoids and Other Antioxidant Vitamins in a Population-based Study. Schünemann, Holger J.; McCann, Susan; Grant, Brydon J. B.; Trevisan, Maurizio; Muti, Paola; Freudenheim, Jo L. // American Journal of Epidemiology;Mar2002, Vol. 155 Issue 5, p463 

    Accumulating evidence suggests that dietary antioxidant vitamins are positively associated with lung function. No evidence exists regarding whether dietary carotenoids other than β-carotene are related to pulmonary function. In 1995–1998 the authors studied the association of forced...

  • Comparison of Lipid Peroxidation and Anti-Oxidant Activities in Pre-Eclamptic & Normal Pregnancies in Nigerian Population. Adeniji, Adetunji O.; Oparinde, Dolapo P. // International Journal of Clinical Medicine;May2013, Vol. 4 Issue 5, p239 

    Purpose: To compare the serum malondialdehyde (MDA) and total antioxidant status in women with preeclampsia and normal pregnancy in our environment. Materials & Methods: This was a 3-year, cross-sectional, case control study of 100 preeclamptic and 200 normotensive pregnant women at Ladoke...

  • Pathogenesis of chronic obstructive pulmonary disease.  // Patient Care for the Nurse Practitioner;Feb2004, Vol. 7 Issue 2, p12 

    The article focuses on the pathogenesis of chronic obstructive pulmonary disease. Central to the Global Initiative for Chronic Obstructive Lung Disease definition of chronic obstructive pulmonary disease (COPD) is an abnormal inflammatory response in the lungs in response to noxious particles or...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics