Medullary Thyroid Carcinoma: An Update on Imaging

Kushchayev, Sergiy V.; Kushchayeva, Yevgeniya S.; Tella, Sri Harsha; Glushko, Tetiana; Pacak, Karel; Teytelboym, Oleg M.
July 2019
Journal of Thyroid Research;7/7/2019, p1
Academic Journal
Medullary thyroid carcinoma (MTC), arising from the parafollicular C cells of the thyroid, accounts for 1–2% of thyroid cancers. MTC is frequently aggressive and metastasizes to cervical and mediastinal lymph nodes, lungs, liver, and bones. Although a number of new imaging modalities for directing the management of oncologic patients evolved over the last two decades, the clinical application of these novel techniques is limited in MTC. In this article, we review the biology and molecular aspects of MTC as an important background for the use of current imaging modalities and approaches for this tumor. We discuss the modern and currently available imaging techniques—advanced magnetic resonance imaging (MRI)-based techniques such as whole-body MRI, dynamic contrast-enhanced (DCE) technique, diffusion-weighted imaging (DWI), positron emission tomography/computed tomography (PET/CT) with 18F-FDOPA and 18F-FDG, and integrated positron emission tomography/magnetic resonance (PET/MR) hybrid imaging—for primary as well as metastatic MTC tumor, including its metastatic spread to lymph nodes and the most common sites of distant metastases: lungs, liver, and bones.


Related Articles

  • Ultrashort Echo Time for Improved Positive-Contrast Manganese-Enhanced MRI of Cancer. Nofiele, Joris Tchouala; Cheng, Hai-Ling Margaret // PLoS ONE;Mar2013, Vol. 8 Issue 3, p1 

    Objective: Manganese (Mn) is a positive magnetic resonance imaging (MRI) contrast agent that has been used to obtain physiological, biochemical, and molecular biological information. There is great interest to broaden its applications, but a major challenge is to increase detection sensitivity....

  • PET-MRI in the head and neck area: challenges and new directions. Castelijns, J. // European Radiology;Nov2011, Vol. 21 Issue 11, p2425 

    The article discusses the challenges and trends on the use of positron emission tomography-magnetic resonance imaging (PET-MRI) in head and neck pathology. It says that the images obtained with PET-MRI system show better detailed resolution and greater image contrast as compared to those from...

  • Ultrasmall Superparamagnetic Particles Of Iron Oxide : Where We Are, Where We Want To Go. Idée, Jean-Marc // AIP Conference Proceedings;10/6/2010, Vol. 1275 Issue 1, p137 

    Ultrasmall superparamagnetic particles of iron oxide have a variety of clinical applications as contrast agents in molecular and cellular magnetic resonance imaging. Physicochemical parameters such as size, surface charge, coating dramatically influence their pharmacokinetic behaviour and, hence...

  • Simultaneous Ga-DOTA-TOC PET/MRI with gadoxetate disodium in patients with neuroendocrine tumor. Hope, Thomas; Pampaloni, Miguel; Nakakura, Eric; VanBrocklin, Henry; Slater, James; Jivan, Salma; Aparici, Carina; Yee, Judy; Bergsland, Emily // Abdominal Imaging;Aug2015, Vol. 40 Issue 6, p1432 

    Objective: To evaluate a simultaneous PET/MRI approach to imaging patients with neuroendocrine tumor using a combination of Ga-DOTA-TOC as a PET contrast agent and gadoxetate disodium as a hepatobiliary MRI contrast agent. Materials and methods: Ten patients with neuroendocrine tumor with known...

  • Synthesis and relaxivity measurement of porphyrin-based Magnetic Resonance Imaging (MRI) contrast agents. Haroon-Ur-Rashid; Umar, M.; Khan, K.; Anjum, M.; Yaseen, M. // Journal of Structural Chemistry;Sep2014, Vol. 55 Issue 5, p910 

    Magnetic Resonance Imaging (MRI) has become a prominent imaging technique in medicine. MRI contrast agents are used to increase the sensitivity of this technique. Recently, a new method for cancer treatment with a less side effect called photodynamic therapy (PDT) has been introduced. In this...

  • Magnetic Resonance Contrast Media Sensing In Vivo Molecular Imaging Agents: An Overview. Amanlou, Massoud; Siadat, Seyed Davar; Norouzian, Dariush; Sadat Ebrahimi, Seyed Esmaeil; Aghasadeghi, Mohammad Reza; Ghorbani, Masoud; Alavidjeh, Mohammad Shafiee; Inanlou, Davoud Nouri; Arabzadeh, Ali Jabbari; Ardestani, Mehdi Shafiee // Current Radiopharmaceuticals;Jan2011, Vol. 4 Issue 1, p31 

    Metabolic imaging is commonly performed by nuclear medicine facilities such as PET or SPECT, etc. The production and biomedical applications of bio-molecular sensing in vivo MRI metabolic contrast agents has recently become of great universal research interest, which follows its great success as...

  • New drugs and dosage forms.  // American Journal of Health-System Pharmacy;3/1/2011, Vol. 68 Issue 5, p366 

    The article provides information on dosage forms of the drugs, Ioflupane 1123 (DaTscan, GE Healthcare) and Spinosad (Natroba, Parapro).

  • Adverse events in nuclear medicine - cause for concern? Hesse, B.; Vinberg, N.; Berthelsen, A.; Ballinger, J. // European Journal of Nuclear Medicine & Molecular Imaging;May2012, Vol. 39 Issue 5, p782 

    The authors reflect on the adverse events in nuclear medicine. They mention the increase in the use of positron emission tomography (PET)/computed tomography (CT) which involves the administration of intravenous or oral contrast media, and the limited availability of PET/magnetic resonance...

  • Absolute quantification of perfusion by dynamic susceptibility contrast MRI using Bookend and VASO steady-state CBV calibration: a comparison with pseudo-continuous ASL. Lindgren, Emelie; Wirestam, Ronnie; Markenroth Bloch, Karin; Ahlgren, André; Osch, Matthias; Westen, Danielle; Surova, Yulia; Ståhlberg, Freddy; Knutsson, Linda // MAGMA: Magnetic Resonance Materials in Physics, Biology & Medici;Dec2014, Vol. 27 Issue 6, p487 

    Objective: Dynamic susceptibility contrast MRI (DSC-MRI) tends to return elevated estimates of cerebral blood flow (CBF) and cerebral blood volume (CBV). In this study, subject-specific calibration factors (CFs), based on steady-state CBV measurements, were applied to rescale the absolute level...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics