Characteristics of Patients with Crimean-Congo Hemorrhagic Fever in a Recent Outbreak in Turkey and Impact of Oral Ribavirin Therapy

Ergönü, Önder; Çlikbaş, Aysel; Dokuzo&gcaron;uz, Başak; Eren, Şebnem; Baykam, Nurcan; Esener, Harika
July 2004
Clinical Infectious Diseases;7/15/2004, Vol. 39 Issue 2, p284
Academic Journal
We describe the epidemiological, clinical, and laboratory findings and the role of ribavirin therapy for 35 patients who received a diagnosis of Crimean-Congo hemorrhagic fever (CCHF). All patients had immunoglobulin M antibodies and/ or PCR results positive for CCHF virus in blood or tissue specimens. Eighty-six percent of the patients were considered to have severe cases of CCHF. The overall case-fatality rate was 2.8%. Eight patients were given ribavirin, and all 8 survived. We suggest using ribavirin to treat patients with CCHF, particularly those with severe cases.


Related Articles

  • The Outcome of Patients with Crimean-Congo Hemmorrhagic Fever in Zahedan, Southeast of Iran: A Comparative Study. Sharifi-Mood, Batool; Metanat, Malihe; Ghorbani-Vaghei, Amin; Fayyaz-Jahani, Farshid; Akrami, Elyas // Archives of Iranian Medicine (AIM);Mar2009, Vol. 12 Issue 2, p151 

    Background: Crimean-Congo hemorrhagic fever was rarely reported from Iran before 1999. In a recent outbreak, the disease has been reported from different provinces of Iran, especially from Sistan and Baluchestan. Ribavirin has been recommended by World Health Organization as a potential...

  • Ribavirin for patients with Crimean–Congo haemorrhagic fever: a systematic review and meta-analysis. Ascioglu, Sibel; Leblebicioglu, Hakan; Vahaboglu, Haluk; Chan, K. Arnold // Journal of Antimicrobial Chemotherapy (JAC);Jun2011, Vol. 66 Issue 6, p1215 

    Background Crimean–Congo haemorrhagic fever (CCHF) is a potentially fatal tick-borne infection. The virus is widely distributed around the world and reports of sporadic cases and outbreaks have recently increased significantly. Some authors have proposed that ribavirin improves survival...

  • Newly Discovered Ebola Virus Associated with Hemorrhagic Fever Outbreak in Uganda. Towner, Jonathan S.; Sealy, Tara K.; Khristova, Marina L.; Albariño, César G.; Conlan, Sean; Reeder, Serena A.; Phenix-Lan Quan; Lipkin, W. Ian; Downing, Robert; Tappero, Jordan W.; Okware, Samuel; Lutwama, Julius; Bakamutumaho, Barnabas; Kayiwa, John; Comer, James A.; Rollin, Pierre E.; Ksiazek, Thomas G.; Nichol, Stuart T. // PLoS Pathogens;Nov2008, Vol. 4 Issue 11, p1 

    Over the past 30 years, Zaire and Sudan ebolaviruses have been responsible for large hemorrhagic fever (HF) outbreaks with case fatalities ranging from 53% to 90%, while a third species, Côte d'Ivoire ebolavirus, caused a single non-fatal HF case. In November 2007, HF cases were reported in...

  • Ãœlkemizde Yeni Ortaya Çıkan Bir Enfeksiyon Hastalığı: Kırım Kongo Kanamalı AteÅŸi. Çiftçi, Ergin // Journal of Pediatric Infection / Cocuk Enfeksiyon Dergisi;May2009 Supplement, Vol. 3 Issue S1, p86 

    Crimean-Congo hemorrhagic fever (CCHF) caused by Nairoviruses, member of Bunyaviridae family, has a high risk of mortality in humans. CCHF virus spreads through tick bite, or direct exposure to infected animal or human blood, body fluids or other infected tissues. Clinical features of the...

  • Kırım-Kongo Kanamalı AteÅŸi Hastalarında Erken Ribavirin Kullanımının Fataliteye Etkisi. Bakir-Özbey, Saliha // Klimik Journal / Klimik Dergisi;Apr2010, Vol. 23 Issue 1, p6 

    Objective: Crimean-Congo haemorrhagic fever (CCHF) is a potentially fatal zoonotic disease. It is mostly encountered in the northeastern part of Turkey, mainly in Tokat, Sivas, Yozgat, Corum and Erzurum provinces. Methods: In this study, clinical, laboratory and epidemiological features of 85...

  • Ribavirin for combined use.  // WHO Drug Information;2001, Vol. 15 Issue 2, p79 

    Reports on the U.S. Food and Drug Administration's approval of ribavirin (Rebetol) capsules, an antiviral used with interferon alfa-2b for the treatment of patients with chronic hepatitis C infection. Stand-alone package of ribavirin; Most important side effect of ribavirin.

  • Pegylated Interferon and Ribavirin Treatment for Hepatitis C Virus Infection. Kagawa, Tatehiro; Keeffe, Emmet B.; Ming-Lung Yu // Hepatitis Research & Treatment;2010, p1 

    An introduction is presented in which the editors discussed various reports published within the issue on topics including the efficacy of interferon in treating chronic hepatitis C, comparison between pegylated interferon with ribavirin, and the side effects of antiviral agents on patients with...

  • Peginterferon-α-2a/ribavirin.  // Reactions Weekly;9/7/2013, Issue 1468, p31 

    The article presents a case study of a 43-year-old male patient who developed pulmonary sarcoidosis during antiviral treatment with peginterferon-beta-2a and ribavirin for chronic hepatitis C infection.

  • Role of cognitive parameters in dengue hemorrhagic fever and dengue shock syndrome. Jih-Jin Tsai; Kulkanya Chokephaibulkit; Po-Chih Chen; Li-Teh Liu; Hui-Mien Hsiao; Yu-Chih Lo; Guey Chuen Perng // Journal of Biomedical Science;2013, Vol. 20 Issue 1, p1 

    Dengue is becoming recognized as one of the most important vector-borne human diseases. It is predominant in tropical and subtropical zones but its geographical distribution is progressively expanding, making it an escalating global health problem of today. Dengue presents with spectrum of...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics