TITLE

Mixed Cytomegalovirus Glycoprotein B Genotypes in Immunocompromised Patients

AUTHOR(S)
Coaquette, Alain; Bourgeois, Alain; Dirand, Carine; Varin, Audrey; Chen, Wan; Herbein, Georges
PUB. DATE
July 2004
SOURCE
Clinical Infectious Diseases;7/15/2004, Vol. 39 Issue 2, p155
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
On the basis of sequence variation in the UL55 gene that encodes glycoprotein B (gB), human cytomegalovirus (CMV) can be classified into 4 gB genotypes. The goal of the present study was to determine the distribution of CMV gB genotypes and the effect of gB type on clinical outcomes in a cohort of immunocompromised patients, including both transplant recipients and nonrecipients. The distribution of gB genotypes was as follows: gBl, 28.9% of patients; gB2, 19.6%; gB3, 23.7%; gB4, 2.0%; and mixed infection, 25.8%. In contrast to patients infected with a single gB genotype, patients infected with multiple gB genotypes developed progression to CMV disease, had an increased rate of graft rejection, had higher CMV loads, and were significantly more often infected with other herpesviruses. The presence of multiple gB genotypes, rather than the presence of a single gB genotype, could be a critical factor associated with severe clinical manifestations in immunocompromised patients.
ACCESSION #
13726771

 

Related Articles

  • Human cytomegalovirus glycoprotein B genotypes in immunocompetent, immunocompromised, and congenitally infected Italian populations. Arista, S.; De Grazia, S.; Giammanco, G. M.; Di Carlo, P.; Iannitto, E. // Archives of Virology;Feb2003, Vol. 148 Issue 3, p547 

    Summary. Human cytomegalovirus (HCMV) strains, obtained from immunocompetent and immunocompromised Italian hosts, were typed with glycoprotein B (gB) gene restriction analysis. A predominant circulation of HCMV strains with gB type 2 and 3 was detected in both the immunocompetent host with a...

  • Cytomegalovirus. Vohr, Hans-Werner // Encyclopedic Reference of Immunotoxicology;2005, p183 

    The article states that the cytomegalovirus causes a systemic infection.

  • Mixed Glycoprotein B Genotypes of Cytomegalovirus and Immunosuppression. Crumpacker, Clyde S. // Clinical Infectious Diseases;7/15/2004, Vol. 39 Issue 2, p162 

    This article presents a commentary note on an article discussing mixed cytomegalovirus (CMV) glycoprotein B genotypes in immunocompromised patients. It is reported that CMV infection remains the most significant infection affecting the outcome of solid-organ transplantation or hematopoietic stem...

  • A Systematic Review and Meta-analysis of Prophylactic versus Pre-emptive Strategies for Preventing Cytomegalovirus Infection in Renal Transplant Recipients. Rawal, B. B.; Shadrou, S.; Abubacker, F.; Ghahramani, N. // International Journal of Organ Transplantation Medicine;2012, Vol. 3 Issue 1, p10 

    In kidney transplant (KT) recipients, CMV infection poses significant morbidity and mortality. Both prophylactic and pre-emptive approaches for preventing CMV infection have been utilized. Objective: To compare the effectiveness of routine prophylaxis vs. pre-emptive treatment for preventing CMV...

  • Cytomegalovirus infections in allogeneic stem cell recipients after reduced-intensity or myeloablative conditioning assessed by quantitative PCR and pp65-antigenemia. Schetelig, J; Oswald, O; Steuer, N; Radonic, A; Thulke, S; Held, T K; Oertel, J; Nitsche, A; Siegert, W // Bone Marrow Transplantation;Oct2003, Vol. 32 Issue 7, p695 

    Summary:Since the incidence of cytomegalovirus (CMV) infections after hematopoietic stem cell transplantation (HSCT) may depend on the intensity of the pretreatment, we studied the incidence of CMV infections after reduced-intensity compared to myeloablative conditioning. A total of 82 patients...

  • Cellular Immunity and Active Human Cytomegalovirus Infection in Patients with Septic Shock. von Müller, Lutz; Klemm, Anke; Durmus, Nilgün; Weiss, Manfred; Suger-Wiedeck, Heide; Schneider, Marion; Hampl, Walter; Mertens, Thomas // Journal of Infectious Diseases;11/1/2007, Vol. 196 Issue 9, p1288 

    Background. Human cytomegalovirus (CMV) is an important opportunistic pathogen after transplantations. In the present study, monitoring of CMV in patients with septic shock was used to discover whether T helper cell type 1 (Th1) cell and natural killer (NK) cell functions interact with CMV...

  • Relationship between TLR4 signalling alterations and effective human cytomegalovirus infection. Germini, D.; Arcangeletti, M. C. // Biopolymers & Cell;2014, Vol. 30 Issue 5, p329 

    Toll-like receptors (TLR), the main class of immune-sensor molecules triggering the innate immunity pathways, are known to be involved in the infection of different RNA and DNA viruses, including herpesviruses. Human cytomegalovirus (HCMV) is a widespread human beta-herpesvirus that infects...

  • Major Expansion of gammasigma T Lymphocytes following Cytomegalovirus Infection in Kidney... Dechanet, Julie; Merville, Pierre; Berge, Frank; Bone-Mane, Gabriel; Taupin, Jean-Luc; Michel, Philippe; Joly, Pierre; Bonneville, Marc; Potaux, Luc; Moreau, Jean-Francois // Journal of Infectious Diseases;1/1/99, Vol. 179 Issue 1, p1 

    Studies the expansion of gammasigma T lymphocyte cells following cytomegalovirus (CMV) infection in the context of therapeutic immunosuppression in kidney transplanted patients. Role of T lymphocytes in host defense; Potential role of gammasigma T lymphocytes in transplantation; Significance of...

  • Immunologic Abnormalities Induced by Postperfusion Cytomegalovirus Infection. Kantor, Gary L.; Goldberg, Leonard S.; Johnson, B. Lamar; Derechin, Michael M.; Barnett, Eugene V. // Annals of Internal Medicine;Oct70, Vol. 73 Issue 4, p553 

    Focuses on a study that investigated clinical and immunologic features in a number of patients with cytomegalovirus-induced postperfusion syndrome. Materials and methods; Results; Discussion.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics