TITLE

The Association of Polymorphisms in Circadian Clock and Lipid Metabolism Genes With 2nd Trimester Lipid Levels and Preterm Birth

AUTHOR(S)
Kovac, Ursa; Jasper, Elizabeth A.; Smith, Caitlin J.; Baer, Rebecca J.; Bedell, Bruce; Donovan, Brittney M.; Weathers, Nancy; Prosenc Zmrzljak, Ursula; Jelliffe-Pawlowski, Laura L.; Rozman, Damjana; Ryckman, Kelli K.
PUB. DATE
June 2019
SOURCE
Frontiers in Genetics;6/13/2019, pN.PAG
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Deregulation of the circadian system in humans and animals can lead to various adverse reproductive outcomes due to genetic mutations and environmental factors. In addition to the clock, lipid metabolism may also play an important role in influencing reproductive outcomes. Despite the importance of the circadian clock and lipid metabolism in regulating birth timing few studies have examined the relationship between circadian genetics with lipid levels during pregnancy and their relationship with preterm birth (PTB). In this study we aimed to determine if single nucleotide polymorphisms (SNPs) in genes from the circadian clock and lipid metabolism influence 2nd trimester maternal lipid levels and if this is associated with an increased risk for PTB. We genotyped 72 SNPs across 40 genes previously associated with various metabolic abnormalities on 930 women with 2nd trimester serum lipid measurements. SNPs were analyzed for their relationship to levels of total cholesterol, high density lipoprotein (HDL), low density lipoprotein (LDL) and triglycerides (TG) using linear regression. SNPs were also evaluated for their relationship to PTB using logistic regression. Five SNPs in four genes met statistical significance after Bonferroni correction (p < 1.8 × 10-4) with one or more lipid levels. Of these, four SNPs were in lipid related metabolism genes: rs7412 in APOE with total cholesterol, HDL and LDL, rs646776 and rs599839 in C ELSR2-PSRC1-SORT1 gene cluster with total cholesterol, HDL and LDL and rs738409 in PNPLA3 with HDL and TG and one was in a circadian clock gene: rs228669 in PER3 with TG. Of these SNPs only PER3 rs228669 was marginally associated with PTB (p = 0.02). In addition, PER3 rs228669 acts as an effect modifier on the relationship between TG and PTB.
ACCESSION #
136978589

 

Related Articles

  • Common genetic variants associated with lipid profiles in a Chinese pediatric population. Shen, Yue; Xi, Bo; Zhao, Xiaoyuan; Cheng, Hong; Hou, Dongqing; Wu, Lijun; Wang, Xingyu; Mi, Jie // Human Genetics;Nov2013, Vol. 132 Issue 11, p1275 

    Genome-wide association (GWA) studies have identified many candidate genes that are associated with blood lipid and lipoprotein concentrations. In this study, we want to know whether the results from European for lipid-related single-nucleotide polymorphisms (SNPs) are generalizable to Chinese...

  • Association of NCOA3 polymorphisms with Dyslipidemia in the Chinese Han population. Mingxi Yu; Gilbert, Siame; Yong Li; Huiping Zhang; Yichun Qiao; Yuping Lu; Yuan Tang; Qing Zhen; Yi Cheng; Yawen Liu // Lipids in Health & Disease;10/9/2015, Vol. 14 Issue 1, p1 

    Background: Nuclear receptor coactivator-3 (NCOA3) is involved in various physiological processes. Emerging evidence from previous studies using animal models suggests that the NCOA3 gene (NCOA3) plays a critical role in lipid metabolism as well as adipogenesis and obesity. The present study...

  • Association of the MLXIPL/TBL2 rs17145738 SNP and serum lipid levels in the Guangxi Mulao and Han populations. Xiao-Na Zeng; Rui-Xing Yin; Ping Huang; Ke-Ke Huang; Jian Wu; Tao Guo; Quan-Zhen Lin; Lynn Htet Aung; Jin-Zhen Wu; Yi-Ming Wang // Lipids in Health & Disease;2013, Vol. 12 Issue 1, p1 

    Background The rs17145738 single nucleotide polymorphism (SNP) near MLX interacting proteinlike/ transducin (beta)-like 2 (MLXIPL/TBL2) loci is associated with serum lipid levels, but the results are inconsistent in diverse ethnic/racial groups. The current study was to investigate the...

  • Sex-specific association of ACAT-1 rs1044925 SNP and serum lipid levels in the hypercholesterolemic subjects.  // Lipids in Health & Disease;2012, Vol. 11 Issue 1, p9 

    The article offers information on the study conducted by the authors related to sex-specific association of Acyl-CoA:cholesterol acyltransferase (ACAT)-1 rs1044925 single nucleotide polymorphism (SNP) and serum lipid levels in the hypercholesterolemic subjects. It states that ACAT is a key...

  • Identifying gene-gene interactions that are highly associated with four quantitative lipid traits across multiple cohorts. De, Rishika; Verma, Shefali; Holzinger, Emily; Hall, Molly; Burt, Amber; Carrell, David; Crosslin, David; Jarvik, Gail; Kuivaniemi, Helena; Kullo, Iftikhar; Lange, Leslie; Lanktree, Matthew; Larson, Eric; North, Kari; Reiner, Alex; Tragante, Vinicius; Tromp, Gerard; Wilson, James; Asselbergs, Folkert; Drenos, Fotios // Human Genetics;Feb2017, Vol. 136 Issue 2, p165 

    Genetic loci explain only 25-30 % of the heritability observed in plasma lipid traits. Epistasis, or gene-gene interactions may contribute to a portion of this missing heritability. Using the genetic data from five NHLBI cohorts of 24,837 individuals, we combined the use of the quantitative...

  • Association of the apolipoprotein M gene polymorphisms and serum lipid levels. Aung, Lynn; Yin, Rui-Xing; Wu, Dong-Feng; Yan, Ting-Ting; Li, Qing; Wu, Jin-Zhen; Lin, Wei-Xiong; Liu, Cheng-Wu; Pan, Shang-Ling // Molecular Biology Reports;Feb2013, Vol. 40 Issue 2, p1843 

    The association of rs707921 and rs707922 SNPs in the apolipoprotein M ( APOM) gene and serum lipid levels is still controversial. This study aimed to detect the association of the APOM rs707921 and rs707922 SNPs and several environmental factors with serum lipid profiles. Genotyping of rs707921...

  • Associations of Cold Receptor TRPM8 Gene Single Nucleotide Polymorphism with Blood Lipids and Anthropometric Parameters in Russian Population. Potapova, T.; Babenko, V.; Kobzev, V.; Romashchenko, A.; Maksimov, V.; Voevoda, M. // Bulletin of Experimental Biology & Medicine;Oct2014, Vol. 157 Issue 6, p757 

    We analyzed associations of single nucleotide polymorphisms rsl13004520 (R247T), rs11562975 (L250L), rs7593557 (S419N), rs11563208 (I1016I), and rs11563071 (V1058V) of the cold receptor TRPM8 (2q37.1) gene with blood plasma lipids and anthropometric parameters in Russian population (randomly...

  • Cholesterol-rich diet induced improvement of hemodynamic system indices in SHR. Portnichenko, G. V.; Goncharov, S. V.; Stroy, D. O.; Dosenko, V. E. // Fiziologichnyi Zhurnal (Physiological Journal);2019, Vol. 65 Issue 2, p68 

    Metabolic syndrome is the nowadays problem that arose as a result of changes in lifestyle and diet. Several of the key factors of this disorder are lipid metabolism disturbances and hypertension. However, there is little known about combined influence of this factors and their contribution to...

  • Polymorphisms of the adiponectin gene in gestational hypertension and pre-eclampsia. Machado, J S R; Palei, A C T; Amaral, L M; Bueno, A C; Antonini, S R; Duarte, G; Tanus-Santos, J E; Sandrim, V C; Cavalli, R C // Journal of Human Hypertension;Feb2014, Vol. 28 Issue 2, p128 

    Adiponectin is a hormone involved in energy homeostasis by regulating glucose and lipid metabolism. In addition, the adiponectin gene (ADIPOQ) has polymorphisms that can modulate the circulating concentration of adiponectin. Abnormal adiponectin levels have been associated with pre-eclampsia...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics