Evidence to support RSV vaccination of the elderly?

Wilkinson, T. M. A.
June 2004
Thorax;Jun2004, Vol. 59 Issue 6, p511
Academic Journal
RSV is an important respiratory pathogen in infants. There is increasing evidence that it also plays a significant role in seasonal morbidity of the elderly and those with underlying cardiopulmonary disease. This study followed two at risk populations for up to two winter seasons: a cohort of healthy elderly subjects and adults with cardiopulmonary disease. A third group of 625 patients admitted acutely into hospital with respiratory symptoms and who were also in either of these at risk groups was also studied. A PCR positive swab, detection of RSV in cell culture, or a fourfold rise in serum IgG to RSV envelope glycoproteins was taken as evidence of RSV infection. Overall, 130 RSV infections were identified over 2 years: 61 in the hospitalized group, 32 in the healthy elderly subjects, and 37 in those with cardiopulmonary disease.


Related Articles

  • Uptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response. Hase, Koji; Kawano, Kazuya; Nochi, Tomonori; Pontes, Gemilson Soares; Fukuda, Shinji; Ebisawa, Masashi; Kadokura, Kazunori; Tobe, Toru; Fujimura, Yumiko; Kawano, Sayaka; Yabashi, Atsuko; Waguri, Satoshi; Nakato, Gaku; Kimura, Shunsuke; Murakami, Takaya; Iimura, Mitsutoshi; Hamura, Kimiyo; Fukuoka, Shin-Ichi; Lowe, Anson W.; Itoh, Kikuji // Nature;11/12/2009, Vol. 462 Issue 7270, p226 

    The mucosal immune system forms the largest part of the entire immune system, containing about three-quarters of all lymphocytes and producing grams of secretory IgA daily to protect the mucosal surface from pathogens. To evoke the mucosal immune response, antigens on the mucosal surface must be...

  • Reporting of perfusion-related incidents: pitfalls and limitations. Svenmarker, Staffan; Appelblad, Micael // Perfusion;Sep2005, Vol. 20 Issue 5, p243 

    Presents a study on the safety and risk-containment associated with cardiopulmonary bypass procedures (CPB). Development of the extracorporeal technology; Concern of air embolism; Inclusion of the historical glimpses of safety assessment in cardiopulmonary bypass.

  • Introduction of Translation Stop Codons into the Viral Glycoprotein Gene in a Fish DNA Vaccine Eliminates Induction of Protective Immunity. Garver, Kyle A.; Conway, Carla M.; Kurath, Gael // Marine Biotechnology;Jul/Aug2006, Vol. 8 Issue 4, p351 

    A highly efficacious DNA vaccine against a fish rhabdovirus, infectious hematopoietic necrosis virus (IHNV), was mutated to introduce two stop codons to prevent glycoprotein translation while maintaining the plasmid DNA integrity and RNA transcription ability. The mutated plasmid vaccine,...

  • Murine gammaherpesvirus 68 glycoprotein 150 does not contribute to latency amplification in vivo. Ruiss, Romana; Ohno, Shinji; Steer, Beatrix; Zeidler, Reinhard; Adler, Heiko // Virology Journal;2012, Vol. 9 Issue 1, p107 

    Background: Murine gammaherpesvirus 68 (MHV-68) is used as a model to study the function of gammaherpesvirus glycoproteins. gp150 of MHV-68, encoded by open reading frame M7, is a positional homolog of gp350/220 of EBV and of gp35/37 of KSHV. Since it had been proposed that gp350/220 of EBV...

  • Study of a test bench for artificial heart valves: description and preliminary results. Mor, Maurizio; Petrogalli, Gianluigi; Mikolajczyk, Tadeusz; Faglia, Rodolfo // Applied Mechanics & Materials;2015, Vol. 783, p17 

    The work described involves the implementation of a testing bench prototype, used to control the behavior of heart valves, taking into account the characteristics of the blood.

  • Autologous tumor-derived heat-shock protein peptide complex-96 (HSPPC-96) in patients with metastatic melanoma. Eton, Omar; Ross, Merrick I.; East, Mary Jo; Mansfield, Paul F.; Papadopoulos, Nicholas; Ellerhorst, Julie A.; Bedikian, Agop Y.; Lee, Jeffrey E. // Journal of Translational Medicine;2010, Vol. 8, p9 

    Background: Glycoprotein-96, a non-polymorphic heat-shock protein, associates with intracellular peptides. Autologous tumor-derived heat shock protein-peptide complex 96 (HSPPC-96) can elicit potent tumor-specific T cell responses and protective immunity in animal models. We sought to...

  • Vaccine safety.  // Weekly Epidemiological Record;10/15/99, Vol. 74 Issue 41, p337 

    Focuses on the significance of vaccination in preventing prevalence of infectious disease. Cost-effectiveness of the medical interventions; Advantages and disadvantages of the vaccination; Application of technology in examining the safety of vaccines.

  • Travel Vaccubatuibs & Malaria Prophylaxis.  // Pulse;5/6/2009, Vol. 69 Issue 15, p30 

    A checklist for monitoring vaccinations and malaria prophylaxis used for travellers in various countries including Argentina, Austria and Costa Rica is presented.

  • TEACHING THE BODY TO FIGHT BACK. Bodach, Vijaya Khisty // Cobblestone;Sep2010, Vol. 31 Issue 7, p10 

    The article discusses the way in which vaccinations help people to not get sick.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics