Fatal Haemophilus influenzae type b sepsis in a 10-month-old infant despite complete vaccination and adequate Hib antibodies

Krueger, Marcus; Fluegge, Kirsten; Krause, Martin F.; Berner, Reinhard
July 2004
European Journal of Pediatrics;2004, Vol. 163 Issue 7, p412
Academic Journal
This article presents information on the occurrence of fatal Haemophilus influenzae type b sepsis in a 10-month-old infant despite complete vaccination and adequate Hib antibodies. Since the implementation of Haemophilus influenzae type b (Hib) vaccine into routine immunisation programmes, the attack rate has decreased from 20-40 to 1/100,000 children under the age of 5 years with a reduction in mortality to about 2.5%. Vaccine failure after regular Hib vaccination is a remarkably rare event. In a recent overview, 115 children with true vaccine failure during a 6-year study period were reported.


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