More on Why Compounds in Grapefruit Interfere With Some Medications

June 2004
Environmental Nutrition;Jun2004, Vol. 27 Issue 6, p7
This article focuses on the adverse impact of grapefruit juice on certain medications. Adverse reactions with certain medications can occur for up to 24 hours after grapefruit or grapefruit juice is consumed. A little over a decade ago, scientists discovered that grapefruit juice contains a substance that blocks the liver's ability to break down certain drugs, resulting in higher than expected levels of the drug in the body and creating the potential for dangerous side effects. Though less common, it can also reduce blood levels of drugs and possibly reduce their effectiveness. The most recent discovery is that some statins, a popular class of cholesterol-lowering drugs, also interact with grapefruit.


Related Articles

  • Forbidden fruit. Roth, Siobhan // National Geographic;Mar2007, Vol. 211 Issue 3, following p16 

    The article offers a look at the health risks of drinking grapefruit juice while taking some oral medicines. The juice can increase the effects and side effects of cholesterol-lowering drugs and other medications by ten because grapefruit it loaded with compounds called furanocoumarins, which...

  • Grapefruit juice influences certain cholesterol drugs.  // Mayo Clinic Health Letter;Mar2000, Vol. 18 Issue 3, p4 

    Focuses on the effect of drinking large amounts of grapefruit juice on blood levels of certain drugs in the group of cholesterol-lowering medications known as statins. Presence of substances that disable certain enzymes in the body; Danger of elevated levels of statins in the blood; Increased...

  • Management of Grapefruit-Drug Interactions. Stump, Amy L.; Mayo, Terri; Blum, Alan // American Family Physician;8/15/2006, Vol. 74 Issue 4, p605 

    Grapefruit is a healthy addition to a well-balanced diet. However, the fruit has been shown to affect the metabolism of many medications, increasing the risk of toxicity and adverse effects. Characteristics of oral medications that may interact with grapefruit include extensive metabolism...

  • nisoldipine.  // Royal Society of Medicine: Medicines;2002, p394 

    This article presents information on the drug nisoldipine, which can be used to prevent heart attacks. It is administered orally. The side effects include headache, dizziness, flushing, nausea, shortness of breath and others. Administer with care to those with certain heart, aortic, kidney or...

  • Interactions with grapefruit juice.  // WHO Drug Information;2003, Vol. 17 Issue 2, p95 

    Reports that the Australian Adverse Drug Reactions Advisory Committee has reevaluated the literature and wishes to revise its advice with regards to drug interactions with grape juice. Response to comments regarding its article published in the volume 21, number 14, 2002 issue of the...

  • Antiradical activity of fruit juices in reactions with diphenylpicrylhydrazyl. Belaya, N. I.; Nikolaevskii, A. N.; Ivleva, T. N.; Sheptura, O. G. // Pharmaceutical Chemistry Journal;Jun2009, Vol. 43 Issue 6, p338 

    The antiradical activity (ARA) of fresh squeezed juices and those reconstituted from concentrate was examined in reactions with diphenylpicrylhydrazyl (DPPH). Fresh squeezed juices contain a higher amount of phenolic substances and exhibit stronger ARA. The maximum ARA among the studied fruit...

  • Verapamil/grapefruit interaction.  // Reactions Weekly;5/16/2009, Issue 1252, p40 

    The article describes the case of a 42-year-old woman who developed various toxicities associated with concomitant ingestion of grapefruit juice while receiving verapamil for migraine. She was admitted to a hospital with a headache of 6 hours' duration and palpitations, progressing to altered...

  • Atorvastatin/grapefruit juice interaction.  // Reactions Weekly;5/10/2008, Issue 1201, p10 

    The article describes the case of a 40-year-old woman who developed rhabdomyolysis associated with concomitant ingestion of grapefruit juice. The patient is receiving atorvastatin for hyperlipidemia and iron-deficiency anaemia. The patient developed low back pain, leg muscle pain and weakness...

  • Drug flaws.  // Alive: Canada's Natural Health & Wellness Magazine;Jan2005, Issue 267, p26 

    The article warns about the use of possibly harmful drugs the grapefruit juice. People can take erythromycin in the juice. The antibiotic is linked to increased risk of heart attack when combined with certain high blood pressure and infection drugs. Potential drug-food and drug-drug interactions...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics