Adverse effects associated with selective serotonin reuptake inhibitors and tricyclic antidepressants: a meta-analysis

Trindade, Evelinda; Menon, Devidas; Topfer, Leigh-Ann; Coloma, Carlos
November 1998
CMAJ: Canadian Medical Association Journal;11/17/98, Vol. 159 Issue 10, p1245
Academic Journal
Presents research which assessed the clinical and economic aspects of selective serotonin reuptake inhibitors (SSRIs) compared with tricyclic antidepressants (TCAs). Increased use of antidepressant medications; Adverse effects of both drugs; Methods; Results; Differing adverse effects; Need for further research related to quality-of-life issues.


Related Articles

  • Antidepressant dependency.  // HealthFacts;Apr98, Vol. 23 Issue 4, p2 

    Discusses the side effects of long-term intake of antidepressants as reported in the 1997 issue of the `International Journal of Risk and Safety in Medicine.' Documentation of significant drug dependency among users of serotonin reuptake inhibitors (SSRI); Symptoms of SSRI withdrawal; Concern...

  • Newer Isn't Necessarily Better.  // People's Medical Society Newsletter;Aug99, Vol. 18 Issue 4, p6 

    Discusses results of studies on antidepressant drugs which were published between 1980 and 1998. Difference with drugs made in the 1990s; Examples of new and old medical treatments; Suggestions on prescribing drugs; Side effects of tricyclic antidepressants and selective serotonin reuptake...

  • Drugs that destroy desire. Scarf, Maggie // Self;Dec96, Vol. 18 Issue 12, p144 

    Reports on the effect of antidepressant medications, particularly selective serotonin reuptake inhibitors (SSRIs), on sexual behavior. Most common sexual problems associated with anti-depressants; Advantages of SSRIs over other medications; Strategies to ameliorate sexual side effects.

  • Prescribing considerations with antidepress ants.  // New Zealand Doctor;9/25/2013, p44 

    The article reports on the factors to be considered when prescribing antidepressants to older people with depression. It highlights the benefits of selective serotonin reuptake inhibitors (SSRIs) with short half-lives, but warns their potential to cause withdrawal reactions upon discontinuation....

  • Antidepressants: associated with risk of GI haemorrhage.  // Reactions Weekly;7/19/2008, Issue 1211, p1 

    The article discusses research being done on the association between antidepressants and the risk of gastrointestinal (GI) hemorrhage. It references a study by F. J. De Abajo and L. A. García-Rodríguez published in the July 2008 issue of "Archives of General Psychiatry." The study suggests...

  • Depression and antidepressant use in Australia. Alchin, Terry; Tranby, Henry // Australian Journal of Social Issues (Australian Council of Socia;May95, Vol. 30 Issue 2, p113 

    This article analyses the use of available antidepressants in Australia. Antidepressants include the tricyclic antidepressants, tetracyclic antidepressants, monoamine oxidase inhibitors (both reversible and non-reversible) and selective serotonin reuptake inhibitors. These groups of...

  • Tamoxifen, SSRIs, and Breast Cancer Recurrence.  // Clinical Cardiology Alert;Sep2009 Pharmacology Watch, p1 

    The article discusses research on the drug interaction between tamoxifen and selective serotonin reuptake inhibitors (SSRI) antidepressants. It references two studies published in the "Journal of Clinical Oncology." One of the studies suggested that the risk of breast cancer recurrence is...

  • Desvenlafaxine. Andrade, Chittaranjan // Indian Journal of Psychiatry;2009, Vol. 51 Issue 4, p320 

    The article analyses the efficacy of the antidepressant drug Desvenlafaxine. It mentions that it has several advantages over venlafaxine including greater efficacy against depression symptoms and lower risk of sustained increase in diastolic blood pressure. But, however venlafaxine is associated...

  • Benign Course in a Child with a Massive Fluoxetine Overdose. Feierabend Jr., Raymond H. // Journal of Family Practice;Sep1995, Vol. 41 Issue 3, p289 

    The selective serotonin reuptake inhibitors appear to have a much wider margin of safety than most other classes of antidepressants. Although there is limited experience with acute overdoses of fluoxetine alone, few serious adverse effects have been reported. There has been almost no experience,...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics