Lung Alert: Abnormalities of Fatty acid metabolism in CF

Bailey, S
May 2004
Thorax;May2004, Vol. 59 Issue 5, p380
Academic Journal
This study found low tissue levels of the fatty acid docosahexaenoic acid (DA) and a raised ratio of arachidonic acid (AA) to DA in patients with cystic fibrosis (CF) compared with healthy controls in nasal and rectal biopsy specimens. In cells from nasal scrapings the AA and DA ratio was also significantly higher in subjects with CF than in controls. Intermediate levels similar to CF carriers were observed in patients with asthma or acute upper respiratory tract infections but lower levels were observed in those with inflammatory bowel disease.


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