Author's reply

Giannini, E. G.; Botta, F.; Testa, R.
June 2004
Gut;Jun2004, Vol. 53 Issue 6, p914
Academic Journal
In this article, the authors, respond to comments made by some researchers, on their research related to gastroenterology. Authors says that as a general rule, a surrogate marker for a given variable, that is, presence/absence of oesophageal varices, that already has a definite diagnostic procedure, that is, endoscopy, should fulfil two major criteria. Firstly, it should be the product of a thorough statistical analysis and secondly, but no less importantly, it has to be biologically plausible. They further say that they have proposed a new evaluation tool and called for validation of proposed method, being conscious that only differences in opinion that arise from results obtained in well conducted studies contribute to scientific progress.


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