A Helicobacter causing colitis? (Book)

June 2004
Gut;Jun2004, Vol. 53 Issue 6, p911
This article focuses on a study related to a Helicobacter causing colitis. Although causes of inflammatory bowel diseases remains to be established, it is recognized that the intestinal flora plays a pivotal role. In an elegant series of experiments, researchers have shown that a T cell clone specific for soluble H hepaticus antigen transferred colitis to T cell deficient H hepaticus infected RAG knockout mice. The study concludes that an aberrant T cell response to specific components of the gut flora is likely to cause some forms of colitis in humans, but it seems too much to hope that H hepaticus is also the culprit.


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