Brittan, M.; Wright, N. A.
June 2004
Gut;Jun2004, Vol. 53 Issue 6, p899
Academic Journal
This article discusses stem cell in gastrointestinal structure and neoplastic development. Stem cells are primitive cells located in a specialized mesenchymal "niche" that lack expression of any definitive markers of lineage commitment and are therefore difficult to define and identify. The early "unitarian hypothesis" states that the epithelial cell lineages of the gastrointestinal tract are clonal populations derived from a single stem cell. Studies of stem cell plasticity have shown that the differentiation pathways of adult cell lineages in the gastrointestinal tract may be less restricted than previously assumed.


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