TITLE

Clinical implications of E-cadherin associated hereditary diffuse gastric cancer

AUTHOR(S)
Filzgerald, R. C.; Comas, C.
PUB. DATE
June 2004
SOURCE
Gut;Jun2004, Vol. 53 Issue 6, p775
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
It has now been established that approximately 1-3% of gastric cancers arise as a result of inherited gastric cancer predisposition syndromes. It is recognized that genetic testing for E-cadherin mutations involves uncertainty about clinical management and disease outcome, and imposes a psychosocial burden on the family member. Prophylactic gastrectomy is clearly a huge undertaking and not without significant psychological and clinical effects on the patient. Long term follow up of gastrectomy patients is required in order to assess their ability to return to work and effects on their quality of life, and to determine whether prophylactic gastrectomy extends life expectancy.
ACCESSION #
13354288

 

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