TITLE

Dermatofibrosarcoma Protuberans and Breast Cancer: Genetic Link or Coincidental Association?

AUTHOR(S)
Beech, Derrick J.; Long, Anne Brown; Long, William Paul
PUB. DATE
June 2004
SOURCE
American Surgeon;Jun2004, Vol. 70 Issue 6, p543
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Dermatofibrosarcoma protuberans is a low-grade cutaneous neoplasm originating from the dermis with a high propensity for local recurrence. These malignancies are classified as soft tissue sarcoma although regional or distance metastatic spread is rare. Germ-line mutations of p53 have been described with a rare autosomal dominant syndrome in patients with soft tissue sarcoma and breast adenocarcinoma (Li Fraumeni's syndrome). The described case illustrates the rare occurrence of dermatofibrosarcoma protuberans (DFSP) and breast adenocarcinoma with an emphasis on the possibility of a molecular or genetic association.
ACCESSION #
13325110

 

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