Manipulation of Central Nervous System Plasticity: A New Dimension in the Care of Neurologically Impaired Patients

Drubach, Daniel A.; Makley, Michael; Dodd, Maryellen L.
June 2004
Mayo Clinic Proceedings;Jun2004, Vol. 79 Issue 6, p796
Academic Journal
Research in the neurosciences in recent decades has shown that the central nervous system is not a structurally static organ as was believed previously, but instead is a dynamic system that constantly undergoes structural and functional reorganization. The term brain plasticity refers to the constant cellular and intercellular modifications that occur during normal development and after neurologic injury and result in changes in neurologic function. The discovery that central nervous system plasticity after injury can be directed toward functional improvement with use of specific modalities has opened up a new dimension in the care of the neurologically impaired patient, termed restorative neurology.


Related Articles

  • CBANHC.  // Canadian Journal of Neurological Sciences;Nov2007 Fall Supplement, Vol. 34, p6 

    The article reports announces the unveiling of "The Burden of Neurological Disease, Disorders and Injuries," a study sponsored by the Canadian Neurological Sciences Federation (CNSF) and its advocacy program, the Canadian Brain and Nerve Health Coalition (CBANHC) during the CNSF annual Congress...

  • Neuronally expressed stem cell factor induces neural stem cell migration to areas of brain injury. Sun, Lixin; Jeongwu Lee; Fine, Howard A. // Journal of Clinical Investigation;May2004, Vol. 113 Issue 9, p1364 

    Neural stem/progenitor cell (NSPC) migration toward sites of damaged central nervous system (CNS) tissue may represent an adaptive response for the purpose of limiting and/or repairing damage. Little is known of the mechanisms responsible for this migratory response. We constructed a cDNA...

  • Autoreactive antibodies against neurons and basal lamina found in serum following experimental brain contusion in rats. Rudehill, S.; Muhallab, S.; Wennersten, A.; von Gertten, C.; Al Nimer, F.; Sandberg-Nordqvist, A. C.; Holmin, S.; Mathiesen, T. // Acta Neurochirurgica;Feb2006, Vol. 148 Issue 2, p199 

    Background. Brain trauma is a risk factor for delayed CNS degeneration which may be attenuated by anti-inflammatory treatment. CNS injuries may cause anti-brain reactivity. This study was undertaken to analyze the pattern of delayed post-traumatic anti-brain immunity in experimental brain...

  • The cytokine tumor necrosis factor-like weak inducer of apoptosis and its receptor fibroblast growth factor-inducible 14 have a neuroprotective effect in the central nervous system.  // Journal of Neuroinflammation;2012, Vol. 9 Issue 1, p45 

    The article presents information on a study conducted on the neuroprotective effect of cytokine tumor necrosis factor-like weak inducer of apoptosis (TWEAK) and its receptor fibroblast growth factor-inducible 14 (Fn14), in hypoxic and ischemic conditions related to the central nervous system....

  • Functional MRI to study brain plasticity in clinical neurology. Rocca, M. A.; Filippi, M. // Neurological Sciences;May2006 Supplement 1, Vol. 27, ps24 

    Functional magnetic resonance imaging (fMRI) is being widely used to study recovery of function in patients with several neurological conditions, including multiple sclerosis, stroke and Alzheimer�s disease. The application of this MR technique has shown that plastic cortical changes do...

  • Non-Convulsive Status Epilepticus Following Hemodynamically Unstable Atrial Fibrillation. Blitshteyn,, Svetlana; Chabolla, David R.; Rubino, Frank A. // Internet Journal of Neurology;2005, Vol. 4 Issue 2, p7 

    Non-convulsive status epilepticus (NCSE) is an increasingly recognized condition in non-epileptic intensive care patients and is seen in up to 8% of patients in coma. NCSE can be a challenging diagnosis because clinical features include altered mental status in the absence of convulsive...

  • Nosocomial ventriculitis and meningitis in neurocritical care patients. Beer, R.; Lackner, P.; Pfausler, B.; Schmutzhard, E. // Journal of Neurology;Nov2008, Vol. 255 Issue 11, p1617 

    External ventricular drainage (EVD) is frequently necessary in neurological and neurosurgical intensive care patients. A major complication of this procedure is an EVD-related venticulitis or meningitis. The purpose of this review is (1) to address the magnitude of the problem in the...

  • FURTHER READING.  // PharmaWatch: CNS;December 2003, Vol. 2 Issue 12, p36 

    Presents information resources available regarding central nervous system diseases, compiled as of December 2003.

  • The Rehabilitation Complexity Scale version 2: a clinimetric evaluation in patients with severe complex neurodisability. Turner-Stokes, Lynne; Williams, Heather; Siegert, Richard J. // Journal of Neurology, Neurosurgery & Psychiatry;Feb2010, Vol. 81 Issue 2, p146 

    Objective To evaluate the clinimetric properties of the Rehabilitation Complexity Scale (RCS) in a neurorehabilitation inpatient sample. Design Observational cohort analysis in a tertiary specialist setting. Subjects 179 consecutive patients (mean age 44.5? years (SD 15-years), males:females...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics