TITLE

Diarrhea and Reduced Levels of Antiretroviral Drugs: Improvement with Glutamine or Alanyl-Glutamine in a Randomized Controlled Trial in Northeast Brazil

AUTHOR(S)
Bushen, Oluma Y.; Davenport, John A.; Lima, Afonso Bezerra; Piscitelli, Stephen C.; Uzgiris, Arejas J.; Silva, Terezinha M. J.; Leite, Roberio; Kosek, Margaret; Dillingham, Rebecca A.; Girao, Arlete; Lima, Aldo A. M.; Guerrant, Richard L.
PUB. DATE
June 2004
SOURCE
Clinical Infectious Diseases;6/15/2004, Vol. 38 Issue 12, p1764
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The effects of therapy with glutamine and alanyl-glutamine on diarrhea and antiretroviral drug levels in patients with acquired immune deficiency syndrome (AIDS) were examined in a randomized, double-blinded, placebo-controlled study in northeast Brazil. Patients with AIDS and with diarrhea and/or wasting were randomized into 4 groups to determine the efficacy of glutamine or high- or low-dose alanyl-glutamine given for 7 days, compared with isonitrogenous glycine given to control subjects. All patients in whom baseline antiretroviral drug levels were determined had low levels 2 h after dosing. Gastrointestinal symptom scores improved with receipt of high-dose alanyl-glutamine (P < .05) or glutamine (P < .01). Antiretroviral drug levels increased in patients given alanyl-glutamine (P = .02) or glutamine (P = .03) by 113% (P = .02) and 14% (P = .01), respectively. Antiretroviral drug resistance mutations were common in all groups. The dose-related efficacy of alanyl-glutamine and glutamine in treating diarrhea and in increasing antiretroviral drug levels shows that these supplements may help to improve therapy for patients with AIDS who have diarrhea and/or wasting in developing, tropical areas.
ACCESSION #
13282107

 

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