TITLE

The Safety and Efficacy of Daptomycin for the Treatment of Complicated Skin and Skin-Structure Infections

AUTHOR(S)
Arbeit, Robert D.; Maki, Dennis; Tally, Francis P.; Campanaro, Edward; Eisenstein, Barry I.
PUB. DATE
June 2004
SOURCE
Clinical Infectious Diseases;6/15/2004, Vol. 38 Issue 12, p1673
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Daptomycin is the first available agent from a new class of antibiotics, the cyclic lipopeptides, that has activity against a broad range of gram-positive pathogens, including organisms that are resistant to methicillin, vancomycin, and other currently available agents. Daptomycin (4 mg/kg intravenously [fri every 24 h for 7-14 days) was compared with conventional antibiotics (penicillinase-resistant penicillins [4-12 g iv per day] or vancomycin [1 g iv every 12 h]) in 2 randomized, international trials involving 1092 patients with complicated skin and skin-structure infections. Among 902 clinically evaluable patients, clinical success rates were 83.4% and 84.2% for the daptomycin- and comparator-treated groups, respectively (95% confidence interval, -4.0 to 5.6). Among patients successfully treated with iv daptomycin, 63% required only 4-7 days of therapy, compared with 33% of comparator-treated patients (P < .0001). The frequency and distribution of adverse events were similar among both treatment groups. Overall, the safety and efficacy of daptomycin were comparable with conventional therapy.
ACCESSION #
13281996

 

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