The Feasibility of a Community-Based Directly Administered Antiretroviral Therapy Program

Wohl, Amy Rock; Garland, Wendy H.; Squires, Kathleen; Witt, Mallory; Larsen, Robert; Kovacs, Andrea; Hader, Shannon; Weidle, Paul J.
June 2004
Clinical Infectious Diseases;6/1/2004 Supplement, Vol. 38, pS388
Academic Journal
Improved treatment-adherence support programs are needed to help human immunodeficiency virus (HIV)- infected persons comply with complex highly active antiretroviral treatment (HAART) regimens. In an experimental directly administered antiretroviral therapy (DAART) program, treatment-naive and treatment-experienced persons who experienced failure of no more than 1 prior regimen were recruited from 3 public HIV/AIDS clinics in Los Angeles County. For 6 months, trained community workers observed ingestion of 1 of 2 daily HAART doses, 5 days per week, and questioned the patient about the second dose, which enabled intense adherence monitoring and real-time intervention. From November 2001 through November 2003, there were 67 DAART patients enrolled (69% Latino, 21% African American, and 9% white; 63% with annual income of <$10,000). Preliminary findings show that a DAART program based in 3 public HIV/AIDS clinics was feasible in a low-income urban population. Effective communication between the DAART staff, the medical providers, and the pharmacy is essential for the successful implementation of this program.


Related Articles

  • Modified Directly Observed Therapy for the Treatment of HIV--Seropositive Substance Users: Lessons Learned from a Pilot Study. Macalino, Grace E.; Mitty, Jennifer A.; Bazerman, Lauri B.; Singh, Kavita; McKenzie, Michelle; Flanigan, Timothy // Clinical Infectious Diseases;6/1/2004 Supplement, Vol. 38, pS393 

    Highly active antiretroviral therapy (HAART) can dramatically decrease human immunodeficiency virus (HIV) load in plasma, increase CD4+ cell counts, and prolong life for HIV-seropositive persons. However, the need for optimal adherence has been recognized. We implemented a pilot community-based...

  • HAART: A Cost-Effective Option for South Africa.  // PLoS Medicine;Jan2006, Vol. 3 Issue 1, pe37 

    The article presents information on a study on the use of highly active antiretroviral therapy (HAART) for the treatment of HIV/AIDS patients in South Africa. The researchers compared the cost of services for a number of patients who were given HAART with the costs for a matched comparison group...

  • Routine Screening for Depression: Identifying a Challenge for Successful HIV Care. Shacham, E.; Nurutdinova, D.; Satyanarayana, V.; Stamm, K.; Overton, E. T. // AIDS Patient Care & STDs;Nov2009, Vol. 23 Issue 11, p949 

    Individuals with HIV experience fluctuating levels of distress throughout the course of HIV infection. This study was conducted to examine the associations of depressive symptomatology with HIV disease in a cohort of individuals who are engaged in routine medical care. This cross-sectional study...

  • "I will not let my HIV status stand in the way." Decisions on motherhood among women on ART in a slum in Kenya- a qualitative study. Ujiji, Opondo Awiti; Ekström, Anna Mia; Ilako, Festus; Indalo, Dorcas; Rubenson, Birgitta // BMC Women's Health;2010, Vol. 10, p13 

    Background: The African Medical Research Foundation antiretroviral therapy program at the community health centre in Kibera counsels women to wait with pregnancy until they reach the acceptable level of 350 cells/ml CD4 count and to discuss their pregnancy intentions with their health care...

  • Building African AIDS Care from the Ground Up.  // Annals of Internal Medicine;7/15/2003, Vol. 139 Issue 2, p157 

    The epicenter of AIDS activity in the early 1980s was San Francisco General Hospital, where Merle Sande, MD, was chief of medicine. Within the next decade, physicians in the United States learned how to treat HIV infection and AIDS as pharmaceutical companies launched drugs that controlled the...

  • Free HIV/AIDS treatment plans kick off in S Africa, China.  // PharmacoEconomics & Outcomes News;5/8/2004, Issue 452, p11 

    Reports on the decision of the South Africa government to administer free antiretrovirals to patients with AIDS. Delay on the launch of the plan due to lack of physicians; Prevention of mother-to-child transmission of HIV under the policy.

  • Trends in AIDS-Defining and Non--AIDS-Defining Malignancies among HIV-Infected Patients: 1989--2002. Bedimo, Roger; Chen, Ray Y.; Accortt, Neil A.; Raper, James L.; Linn, Carol; Allison, Jeroan J.; Dubay, John; Saag, Michael S.; Hoesley, Craig J. // Clinical Infectious Diseases;11/1/2004, Vol. 39 Issue 9, p1380 

    In a comparison of rates of acquired immunodeficiency syndrome (AIDS)-defining malignancies (ADMs) for 1989-1996 versus 1997-2002, we found a decrease in ADMs (rate ratio, 0.31; P<.0001) and a significant increase in non-AIDS-defining malignancies (non-ADMs; rate ratio, 10.87; P<.0002). The mean...

  • Editorial Response: Time for a New Paradigm--Optimal Management Patients with Human Immunodeficiency Virus Infection and AIDS.  // Clinical Infectious Diseases;1/1/1999, Vol. 28 Issue 1, p23 

    Focuses on the debate on how to organize medical care for patients with HIV infection. Decentralization of care for HIV infection among primary care providers; Inexperience of providers or hospitals leading to treatment differences.

  • A Walk for Life.  // 21st Century;Nov92, Vol. 4 Issue 3, p11 

    The author reflects on AIDS as a medical condition in the U.S. The author cites the event "From All Walks of Life," a walk for a cause, dedicated to all people with AIDS. The author states that it can be prevented but it may take away a life of a person. The author mentions that AIDS is real and...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics