Topical Mupirocin and Catheter-Related Bacteremia

Allon, Michael
June 2004
Clinical Infectious Diseases;6/1/2004, Vol. 38 Issue 11, p1641
Academic Journal
The randomized study by D.W. Johnson and colleagues on the use of an investigational catheter lock solution (CLS) for the prevention of tunneled hemodialysis catheter-related bacteremia (CRB) demonstrated a substantial reduction in CRB by the application of topical mupirocin at the dialysis catheter exit site. Mupirocin has antibiotic activity only against gram-positive cocci. Although it is true that only 12.5% of our control patients with CRB had cultures that grew a gram-negative rod, the proportion of gram-negative bacterial infections among hemodialysis patients with CRB has been as high as 40%-45% in some reports.


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