The Use and Interpretation of Quasi-Experimental Studies in Infectious Diseases

Harris, Anthony D.; Bradham, Douglas D.; Baumgarten, Mona; Zuckerman, Ilene H.; Fink, Jeffrey C.; Perencevich, Eli N.
June 2004
Clinical Infectious Diseases;6/1/2004, Vol. 38 Issue 11, p1586
Academic Journal
Quasi-experimental study designs, sometimes called nonrandomized, pre-post-intervention study designs, are ubiquitous in the infectious diseases literature, particularly in the area of interventions aimed at decreasing the spread of antibiotic-resistant bacteria. Little has been written about the benefits and limitations of the quasi-experimental approach. This article outlines a hierarchy of quasi-experimental study design that is applicable to infectious diseases studies and that, if applied, may lead to sounder research and more-convincing causal links between infectious diseases interventions and outcomes.


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