TITLE

Clinicopathological and Prognostic Features of Surgical Management in Duodenal Gastrointestinal Stromal Tumors

AUTHOR(S)
Shi, Hong Peng; Huang, Min Lu; Wang, Zhen Qiang; Zheng, Ya Nan; Zhu, Zheng Lun; Sah, Birendra Kumar; Liu, Wen Tao; Yan, Min; Zhu, Zheng Gang; Li, Chen
PUB. DATE
October 2018
SOURCE
Digestive Surgery;Oct2018, Vol. 35 Issue 6, p498
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background and Objectives: The rarity of duodenal gastrointestinal stromal tumors (DGIST) led to only limited data being available on their management and prognosis. We retrospectively analyzed the clinicopathological features, surgical treatments, adjuvant therapy, and prognosis of DGIST. Methods: Sixty-one patients were identified at diagnosis of primary DGIST from February 2005 to December 2015. One hundred twenty six patients with small intestinal gastrointestinal stromal tutors (GIST) were selected as control groups. Survival analyses were calculated using the Kaplan-Meier method. Results: Three- and five-year recurrence/metastasis-free survival rates of patients with DGIST were similar to those of patients with small intestinal GIST (p > 0.05 for all). Out of 61 cases with DGIST, 45 patients were treated with Limited Resection (LR). Sixteen patients were treated with Pancreaticoduodenectomy (PD). The 3- and 5-year recurrence/metastasis-free survival rates of the PD group and LR group were of no significant difference (p > 0.05 for all). Univariate analysis indicated that factors including surgical approaches, mitotic count, size, and risk grades were significantly associated with recurrence/metastasis-free survival (log-rank test, p < 0.05). Multivariate analysis demonstrated that the mitotic count was independently correlated with a worse recurrence/metastasis-free survival. Conclusions: Patients with radical resected DGIST had a favourable prognosis, which is similar to that of small intestinal GIST. Both LR and PD were optimal choices for treating DGIST.
ACCESSION #
132337474

 

Related Articles

  • Simple segmental resection of the second portion of the duodenum for the treatment of gastrointestinal stromal tumors. Asakawa, Masami; Sakamoto, Yoshihiro; Kajiwara, Takahiro; Nara, Satoshi; Esaki, Minoru; Shimada, Kazuaki; Hamaguchi, Tetsuya; Kosuge, Tomoo // Langenbeck's Archives of Surgery;Jul2008, Vol. 393 Issue 4, p605 

    Adequate surgical procedure for gastrointestinal stromal tumors (GISTs) arising in the second portion of the duodenum remains controversial. Segmental resection of the second portion of the duodenum and Roux-en-Y reconstruction was performed in two patients with duodenal GISTs. In case 1, a huge...

  • Management and outcome of gastrointestinal stromal tumors of the duodenum. Jun Chul Chung; Chong Woo Chu; Gyu Seok Cho; Eung Jin Shin; Chul Wan Lim; Hyung Chul Kim; Ok Pyung Song; Chung, Jun Chul; Chu, Chong Woo; Cho, Gyu Seok; Shin, Eung Jin; Lim, Chul Wan; Kim, Hyung Chul; Song, Ok Pyung // Journal of Gastrointestinal Surgery;May2010, Vol. 14 Issue 5, p880 

    Background: Duodenal gastrointestinal stromal tumors (GISTs) are uncommon and relatively small subset of GISTs whose optimal surgical procedure has not been well defined. We conducted this study to present the surgical experience in our institution and to analyze the postoperative...

  • Pancreas-preserving total duodenectomy: a 10-year experience. Penninga, Luit; Svendsen, Lars // Journal of Hepato -- Biliary -- Pancreatic Sciences;Sep2011, Vol. 18 Issue 5, p717 

    Background: Traditionally, severe pathology of the duodenum has been treated by a pancreaticoduodenectomy using Whipple's operation. Pancreas-preserving total duodenectomy (PPTD) was introduced in the late 1990s as an alternative to Whipple's operation for selected diseases of the duodenum. We...

  • Gastrointestinal Stromal Tumors: A Single Institution Experience of 176 Surgical Patients. FISHER, SARAH B.; KIM, STEVEN C.; KOOBY, DAVID A.; CARDONA, KENNETH; RUSSELL, MARIA C.; DELMAN, KEITH A.; STALEY III, CHARLES A.; MAITHEL, SHISHIR K. // American Surgeon;Jul2013, Vol. 79 Issue 7, p657 

    Large single-institution series of patients undergoing resection for gastrointestinal stromal tumors (GIST) are lacking. Clinicopathologic characteristics and postoperative outcomes were retrospectively collected and analyzed from patients undergoing resection for GIST from 2002 to 2011. One...

  • Partial duodenectomy with end-to-end anastomosis for duodenal gastrointestinal stromal tumor. Cavaniglia, Daniele; Lorenzon, Laura; Caterino, Salvatore; Cavallini, Marco; Petrucciani, Niccolò; Petrucciani, Niccolò // American Surgeon;May2012, Vol. 78 Issue 5, pE273 

    The article describes the case of a 56-year-old woman who was diagnosed with duodenal gastrointestinal stromal tumor (GIST). Her medical history included sideropenic anemia and fatigue. GIST was detected via esophagogastroduodenoscopy, while an eco-endoscopy was able to identify the origin of...

  • Gastrointestinal Stromal Tümör Nedeniyle Duodenum Üçüncü Segment Rezeksiyonu: Olgu Sunumu. Özer, Mustafa Tahir; Demirbaş, Sezai; Harlak, Ali; Eryılmaz, Mehmet; Arslan, İsmail; Tufan, Turgut // Erciyes Medical Journal / Erciyes Tip Dergisi;2009, Vol. 31 Issue 1, p083 

    We present a case of duodenal Gastrointestinal Stromal Tumors (GIST) who underwent a segmental resection of the third part. Ultrasound and computed tomography (CT) exposed a 10x15 cm. mass that the borders could not be clearly distinguished from duodenum and did not cause obstruction. A pancreas...

  • Local Resection of a Gastrointestinal Stromal Tumor of the Third Portion of the Duodenum. Cubas, Robert Frank; Ballarino, Enrique Abel; Nieto, Felix Augusto; Diaz, Marcelo Demetrio // American Surgeon;Jan2012, Vol. 78 Issue 1, pE22 

    The article focuses on the resection of gastrointestinal stromal tumors (GISTs) of the duodenum. It discusses the case of a 64-year-old woman with intermittent melena and asthenia. Computed tomography (CT) showed a tumor in the third portion of the duodenum. An exploratory laparotomy was...

  • Tumores del Estroma Gastrointestinal (GIST): Características Clinico-Morfológicas y Perfil Inmunohistoquímico.  // International Journal of Morphology;2011, Vol. 29 Issue 1, p244 

    No abstract available.

  • Leczenie chirurgiczne nowotworów podÅ›cieliskowych przewodu pokarmowego (GIST). Ruka, Włodzimierz; Rutkowski, Piotr; Zdzienicki, Marcin; Nowecki, Zbigniew I. // Gastroenterologia Polska / Gastroenterology;2009, Vol. 16 Issue 2, p129 

    Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of gastrointestinal tract. The activating mutation of KIT or PDGFRA genes is initial step in their carcinogenesis process; over expression of KIT receptor, as a consequence of mutation of protooncogene KIT, is highly...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics