A clinical prediction rule containing 6 variables accurately predicted hypersensitivity pneumonitis: COMMENTARY

Lake, Fiona
May 2004
ACP Journal Club;May/Jun2004, Vol. 140 Issue 3, p81
Academic Journal
Hypersensitivity pneumonitis (HP), an uncommon interstitial disease related to a reaction to an inhaled allergen, can present in diverse ways. Accurate diagnosis is important for differentiating HP from other interstitial disorders because the prognosis and treatment may differ or different allergens may need to be avoided. No gold standard exists for the diagnosis of HP, and clinicians review many aspects of presentation and investigation to reach a diagnosis. Such assessments viewed in isolation lack specificity to make a confident diagnosis. The clinical features are easily obtainable, although with the precipitins assays may not be available locally, values may fluctuate, or precipitins may not be present in some forms of HP. However, if the other measures, including exposure to a recognized antigen, are present, the probability of having HP still remains acceptably high.


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