Patients with West Nile virus meningitis or encephalitis, but not acute flaccid paralysis, had favorable outcomes

May 2004
ACP Journal Club;May/Jun2004, Vol. 140 Issue 3, p78
Academic Journal
This article presents a study, to determine the long-term outcome for patients with neurologic manifestations of West Nile virus (WNV) infection. 16 patients, with confirmed WNV infection were detected. WNV-specific antibodies were detected in acute-phase serum or cerebrospinal fluid samples by IgM antibody-capture enzyme-linked immunosorbent assay and by plaque-reduction neutralization assay. 5 patients had West Nile meningitis (WNM), 8 had West Nile encephalitis, and 3 had poliomyelitis-like acute flaccid paralysis. The median time from illness onset to presentation was 2.5 days. Among patients with WNV infection, those with WNV meningitis and WNV encephalitis had favorable outcomes, but those with acute flaccid paralysis did not recover limb strength.


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