An exercise and behavioral management program reduced functional dependence in Alzheimer disease: COMMENTARY

Stott, David J.; Taylor, Morven
May 2004
ACP Journal Club;May/Jun2004, Vol. 140 Issue 3, p77
Academic Journal
Many clinicians question the effectiveness of rehabilitation for patients with Alzheimer disease. Emphasis is often placed on introducing coping strategies, rather than active rehabilitation with the aim of improving physical function, mood, and behavior. Few good clinical trials exist on which to base clinical practice. No previous trial has been done of combined exercise and behavioral management in Alzheimer disease. The selection process in the study conducted, resulted in enrollment of about 40% of eligible patients and caregivers. The exercise and caregiver interventions are complex, but are clearly described and could be replicated. Validated outcome measures were used, with blinded observers. The statistical analyses are appropriate. The study is adequately powered to detect effects of the intervention on functional outcome, but is underpowered to detect any reduction in institutionalization.


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