Review: Metformin used alone or combined with clomifene may improve ovulation rates in the polycystic ovary syndrome: COMMENTARY

Hoeger, Kathleen M.; Guzick, David S.
May 2004
ACP Journal Club;May/Jun2004, Vol. 140 Issue 3, p75
Academic Journal
Polycystic ovary syndrome (PCOS) is characterized by oligo-ovulation, irregular menses, and symptoms of androgen excess, such as hirsutism and acne. It is a common endocrinopathy affecting 5% to 10% of women of reproductive age. Insulin resistance is felt to play a key role in most women with PCOS, therefore insulin-sensitizing agents have moved to the forefront of management of PCOS. No large-scale, long-term studies of their use in PCOS have been reported thus far. This study combines the results of 15 randomized clinical trials (RCT) using insulin-sensitizing agents in the treatment of PCOS. The primary outcome measure in 11 of the 15 RCTs was ovulation. Because data are mainly available for metformin use, the conclusions are essentially restricted to this drug.


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