Review: Metformin used alone or combined with clomifene may improve ovulation rates in the polycystic ovary syndrome

May 2004
ACP Journal Club;May/Jun2004, Vol. 140 Issue 3, p75
Academic Journal
This article presents a study, which examines the effectiveness of insulin-sensitizing drugs, in women with the polycystic ovary syndrome (PCOS). Studies were selected if they were randomized controlled trials, that compared insulin-sensitizing drugs with placebo, no treatment, or an ovulation-inducing agent in women with PCOS based on biochemical or ultrasonographic evidence. Studies were assessed for allocation concealment, blinding, loss to follow-up, noncompliance, and whether analysis was by intention to treat. Metformin used alone or combined with clomifene is effective for improving ovulation rates in women with the POCS.


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