Review: Metformin used alone or combined with clomifene may improve ovulation rates in the polycystic ovary syndrome

May 2004
ACP Journal Club;May/Jun2004, Vol. 140 Issue 3, p75
Academic Journal
This article presents a study, which examines the effectiveness of insulin-sensitizing drugs, in women with the polycystic ovary syndrome (PCOS). Studies were selected if they were randomized controlled trials, that compared insulin-sensitizing drugs with placebo, no treatment, or an ovulation-inducing agent in women with PCOS based on biochemical or ultrasonographic evidence. Studies were assessed for allocation concealment, blinding, loss to follow-up, noncompliance, and whether analysis was by intention to treat. Metformin used alone or combined with clomifene is effective for improving ovulation rates in women with the POCS.


Related Articles

  • Review: Metformin used alone or combined with clomifene may improve ovulation rates in the polycystic ovary syndrome: COMMENTARY. Hoeger, Kathleen M.; Guzick, David S. // ACP Journal Club;May/Jun2004, Vol. 140 Issue 3, p75 

    Polycystic ovary syndrome (PCOS) is characterized by oligo-ovulation, irregular menses, and symptoms of androgen excess, such as hirsutism and acne. It is a common endocrinopathy affecting 5% to 10% of women of reproductive age. Insulin resistance is felt to play a key role in most women with...

  • Responsive to Thiazolidinediones but not Metformin.  // Fertility Weekly;2/16/2009, p7 

    The article discusses the usefulness of insulin sensitivity and adipose tissue topography to determine proper treatment for patients with polycystic ovary syndrome (PCOS). It is found that PCOS is a common endocrine disorder that affects nearly seven percent of reproductive aged women....

  • Clinical and Hormonal Profile of Polycystic Ovary Syndrome. Begum, Ferdousi // Journal of South Asian Federation of Obstetrics & Gynecology;May-Aug2009, Vol. 1 Issue 2, p22 

    Objectives: The objectives of the study were to find out the clinical features, biochemical and hormonal profile of patients with polycystic ovary syndrome (PCOS) in Bangladesh. Material and Methods: A case control and cross-sectional study was undertaken among 78 PCOS patients attending...

  • Polycystic ovaries identified as function of age. Altersitz, Katrina; Costa, Samantha // Endocrine Today;Dec2013, Vol. 11 Issue 12, p27 

    The article reports that according to a recent data, researchers want revision in the criterion of what constitutes polycystic ovary morphology according to the ultrasound observation of patients after age 30 to 35 years.

  • Ultrasound not necessary to diagnose PCOS.  // Pulse;2/8/2012, Vol. 72 Issue 5, p10 

    The article reports that the diagnosis of polycystic ovaries (PCOS) can be made without the need to undergo ultrasound.

  • The excess in 2-5 mm follicles seen at ovarian ultrasonography is tightly associated to the follicular arrest of the polycystic ovary syndrome. Didier Dewailly; Sophie Catteau-Jonard; Anne-Céline Reyss; Catherine Maunoury-Lefebvre; Edouard Poncelet; Pascal Pigny // Human Reproduction;Jun2007, Vol. 22 Issue 6, p1562 

    BACKGROUND We previously hypothesized that the excess of 2–5 mm follicles seen at ovarian ultrasonography might be involved in the follicular arrest (FA) of polycystic ovary syndrome (PCOS), independently from the main putative contributors of FA, namely hyperandrogenism and...

  • When should we use metformin in PCOS? Franks, Stephen // Pulse;11/3/2003, Vol. 63 Issue 44, p96 

    Determines which women with polycystic ovary syndrome (PCOS) should receive metformin. Lack of randomized controlled trials to assess efficacy of metformin; Support for the notion that metformin improves the frequency of ovulation.

  • Evaluation of Ovarian Cysts. HOLZER, ROBIN A.; PERSONS, ROBERT K.; JAMIESON, BARBARA // American Family Physician;8/1/2011, Vol. 84 Issue 3, p3 

    The article provides an answer to a question of what type of follow-up should a physician conduct for a patient with an ovarian cyst identified on ultrasonography.

  • Effective Management of Anovulation with Ovarian Interstitial YAG-Laser.  // Fertility Weekly;10/23/2006, p2 

    The article presents a study which evaluates the efficiency of ultrasound-guided transvaginal ovarian interstitial laser in treating anovulation in women with polycystic ovary syndrome (PCOS). Serum hormonal levels, spontaneous ovulation rates, and pregnancy rates were examined in anovulatory...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics