Review: Spironolactone may be effective for hirsutism but data are lacking on its effectiveness for acne vulgaris in women

May 2004
ACP Journal Club;May/Jun2004, Vol. 140 Issue 3, p74
Academic Journal
This article presents a study to examine the role of spironolactone, used alone or combined with steroids, to reduce excess hair growth, acne, or both in women. Studies were selected if they were randomized controlled trials comparing spironolactone with placebo, spironolactone with steroids, different dosages of spironolactone, or spironolactone in combination with steroids with steroids alone for reducing hirsutism, acne, or both in women of reproductive or postmenopausal years. Studies of women with hirsutism secondary to a functional androgenic tumor, or iatrogenic or nonendocrine causes of hyperandrogenism or hirsutism were excluded. Studies were assessed for methodologic quality.


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