Review: Commonly used antihypertensive therapies and targeted blood pressure-lowering regiments reduce cardiovascular events

May 2004
ACP Journal Club;May/Jun2004, Vol. 140 Issue 3, p72
Academic Journal
This article presents a study, which states that in patients at increased risk for cardiovascular disease, blood pressure-lowering regimens of different drug classes and regimens targeting different BP goals compare in reducing major cardiovascular events (MCEs). 29 RCTs, with mean follow-up of 2 to 8.4 years met the selection criteria. Compared with placebo, regimens containing angiotensin-converting enzyme inhibitors reduced the risk for MCEs and total mortality, and calcium antagonists reduced the risk for MCEs. In patients at increased risk for cardiovascular disease, regimens of commonly used antihypertensives and those that target blood-pressure lowering reduce the risks for major cardiovascular events.


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